Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging |
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| Authors: | S Omodaka H Endo K Niizuma M Fujimura T Inoue K Sato S-i Sugiyama T Tominaga |
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| Institution: | aFrom the Departments of Neurosurgery (S.O., H.E.);bNeuroendovascular Therapy (K.S.);cNeuroanesthesia (S.-i.S.), Kohnan Hospital, Sendai, Japan;dDepartment of Neurosurgery (K.N., M.F., T.T.), Tohoku University Graduate School of Medicine, Sendai, Japan;eDepartment of Neurosurgery (T.I.), Sendai Medical Center, Sendai, Japan. |
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| Abstract: | BACKGROUND AND PURPOSE:The incidence of wall enhancement of cerebral aneurysms on vessel wall MR imaging has been described as higher in ruptured intracranial aneurysms than in unruptured intracranial aneurysms, but the difference in the degree of enhancement between ruptured and unruptured aneurysms is unknown. We compared the degree of enhancement between ruptured and unruptured intracranial aneurysms by using quantitative MR imaging measures.MATERIALS AND METHODS:We performed quantitative analyses of circumferential enhancement along the wall of cerebral aneurysms in 28 ruptured and 76 unruptured consecutive cases by using vessel wall MR imaging. A 3D-T1-weighted fast spin-echo sequence was obtained before and after contrast media injection, and the wall enhancement index was calculated. We then compared characteristics between ruptured and unruptured aneurysms.RESULTS:The wall enhancement index was significantly higher in ruptured than in unruptured aneurysms (1.70 ± 1.06 versus 0.89 ± 0.88, respectively; P = .0001). The receiver operating characteristic curve analysis found that the most reliable cutoff value of the wall enhancement index to differentiate ruptured from unruptured aneurysms was 0.53 (sensitivity, 0.96; specificity, 0.47). The wall enhancement index remained significant in the multivariate logistic regression analysis (P < .0001).CONCLUSIONS:Greater circumferential enhancement along the wall of cerebral aneurysms correlates with the ruptured state. A quantitative evaluation of circumferential enhancement by using vessel wall MR imaging could be useful in differentiating ruptured from unruptured intracranial aneurysms.Vessel wall MR imaging with a 3D-T1-weighted FSE sequence has been increasingly used to study intracranial vascular lesions such as atherosclerosis, vasculitis, and aneurysms.1–4 Previous reports established a link between ruptured aneurysms and wall enhancement by using qualitative vessel wall MR imaging assessments.1,5,6 However wall enhancement was also observed in unruptured aneurysms1,6; thus, we hypothesized that the degree of enhancement is higher in ruptured than in unruptured aneurysms. In this study, we used a quantitative method to compare the degree of enhancement between ruptured and unruptured intracranial aneurysms by using a 3D-T1WI FSE sequence. |
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