| 红景天苷防治帕金森病的药理作用研究进展 |
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| 引用本文： | 王成麟,刘爽. 红景天苷防治帕金森病的药理作用研究进展[J]. 现代药物与临床, 2023, 38(11): 2903-2908 |
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| 作者姓名： | 王成麟 刘爽 |
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| 作者单位： | 潍坊医学院 临床医学院, 山东 潍坊 261053;山东第一医科大学附属中心医院 神经内科, 山东 济南 250013 |
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| 摘 要： | 帕金森病已成为威胁老年人身心健康的主要疾病之一。红景天苷是从红景天中提取的主要活性化合物之一,具有多种药理作用。红景天苷可通过抑制细胞凋亡、增强细胞自噬、降低氧化应激反应、降低炎症反应、促进胶质细胞源性神经营养因子的表达、提高多巴胺转运蛋白的表达以达到防治帕金森病的作用。总结了红景天苷防治帕金森病的药理作用及其作用机制,为红景天苷的临床使用提供参考。
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| 关 键 词： | 红景天苷 帕金森病 细胞凋亡 细胞自噬 氧化应激 炎症反应 |
| 收稿时间： | 2023-09-12 |
Advances in pharmacological effects of salidroside in prevention and treatment of Parkinson''s disease |
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| WANG Cheng-lin,LIU Shuang. Advances in pharmacological effects of salidroside in prevention and treatment of Parkinson''s disease[J]. Drugs & Clinic, 2023, 38(11): 2903-2908 |
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| Authors: | WANG Cheng-lin LIU Shuang |
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| Affiliation: | School of Clinical Medicine, Weifang Medical University, Weifang 261053, China; Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China |
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| Abstract: | Parkinson''s disease has become one of the main diseases threatening the physical and mental health of the elderly. Salidroside is one of the main active compounds from Rhodiolae Crenulatae Radix et Rhizoma, and has various pharmacological effects. Salidroside can prevent and treat Parkinson''s disease by inhibiting cell apoptosis, enhancing autophagy, reducing oxidative stress, reducing inflammation, promoting the expression of GDNF, and increasing the expression of dopamine transporter. This article summarizes the pharmacological effects and their mechanisms of salidroside in the prevention and treatment of Parkinson''s disease, providing evidence for the clinical use of salidroside. |
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| Keywords: | salidroside Parkinson''s disease cell apoptosis autophagy oxidative stress inflammatory response |
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