Population genetic data of 38 insertion-deletion markers in six populations of the northern fringe of the Iberian Peninsula |
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| Institution: | 1. BIOMICs Research Group, Centro de Investigación “Lascaray” Ikergunea, Universidad del País Vasco UPV/EHU, Vitoria-Gasteiz, Spain;2. Servicio de Patología ? Gipuzkoa ? del IVML (Instituto Vasco de Medicina Legal), Dpto. de la Administración de Justicia, Gobierno Vasco, Spain;3. Unidad de Medicina Legal, Facultad de Medicina, Universidad de Cantabria, Santander, Spain;4. Departamento de Medicina Legal, Universidad de Zaragoza, Zaragoza, Spain;1. Institute of Brain and Behavioral Science, College of Life Sciences, Shaanxi Normal University, Xi''an, Shaanxi 710062, China;2. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China;3. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China;4. Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China;1. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi''an, Shaanxi 710004, China;2. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi''an, Shaanxi 710004, China;1. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi''an, Shaanxi 710004, China;2. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi''an, Shaanxi 710004, China;3. Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China;1. Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Beijing, 100038, China;2. Technology Department of Chaoyang Sub-Bureau, Beijing Public Security Bureau, Beijing, 100102, China;1. Institute of Forensic Sciences Luis Concheiro, Genomics Medicine Group, University of Santiago de Compostela, Santiago de Compostela, Spain;2. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia;1. Department of Biomedicine & Prevention, School of Medicine, University of Rome “Tor Vergata”, Rome, Italy;2. Laboratory of Genomic Medicine, Fondazione Santa Lucia IRCCS, Rome, Italy |
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| Abstract: | Insertion-deletions have been reported very useful markers for forensic purposes. To further deepen in this matter, 38 non-coding bi-allelic autosomal indels were analyzed in 575 individuals representing six populations from the northern fringe of the Iberian Peninsula. Autochthonous populations from the Basque Country, northern Navarre, the Pas Valley in Cantabria and Aragon were analyzed, together with non-autochthonous populations from the Basque Country and northern Navarre. At the intra-population level, all loci analyzed were in Hardy-Weinberg equilibrium except for marker rs33917182 in autochthonous Basques. Linkage disequilibrium (LD) test did not reveal statistically significant allelic association between the different loci pairs in all six populations. Forensic parameters proved to be highly informative in the six populations analyzed, even if a scenario with population substructure and local inbreeding was considered for match probability calculations, and the potential of this indels set to be used in combination with other genetic markers is remarkable. As for inter-population analyses, in general terms the six populations showed low but statistically significant genetic distances. However, though this indels set efficiently differentiate between main ancestries, it does not allow an accurate separation at a local level and, for the time being, their combination with other informative markers is needed to maximize the power to accurately differentiate populations with close genetic ancestry. |
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| Keywords: | Indels Iberian Peninsula Autochthonous Basques Navarre Pas valley Aragon |
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