Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials |
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| Affiliation: | 1. Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People''s Republic of China;2. Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People''s Republic of China;3. Wuhan Tongji Reproductive Medicine Hospital, Wuhan, People''s Republic of China;1. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;2. Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;3. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA;1. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA;2. Department of Obstetrics and Gynecology, New York University School of Medicine, 4 Columbus Circle, Fourth Floor, New York, NY 10019, USA;1. Department of Sports Science and Wellness, “Parthenope” University Naples, Naples, Italy;2. Endocrinology and Diabetology, Fertility Techniques Structure, University Hospital “S. Giovanni di Dio e Ruggi d’Aragona”, Largo Città d’Ippocrate, Salerno, Italy;3. Ios and Coleman Medicina Futura Medical Center, Naples, Italy;4. Department of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey;5. Unit of Obstetrics and Gynaecology, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, University of Modena and Reggio Emilia, Reggio Emilia, Italy;6. Department of Clinical Medicine and Surgery, University “Federico II” Naples, Italy;7. Department of Exercise Science and Wellness, “Parthenope” University Naples, Naples, Italy;8. Fertility Techniques Structure, “S. Giovanni di Dio e Ruggi d’Aragona” University Hospital Salerno, Salerno, Italy;1. Department of Pediatrics, Ain-Shams University, Cairo, Egypt;2. Department of Obstetrics and Gynaecology, Al-Azhar University, Cairo, Egypt |
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| Abstract: | ObjectiveTo evaluate the effect of vitamin D supplementation on patients with PCOS.MethodsWe performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients.Main resultsNine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39).ConclusionsEvidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS. |
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| Keywords: | PCOS Vitamin D RCTs Meta-analysis |
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