| 糙叶败酱中木脂素成分研究糙叶败酱中木脂素成分研究 |
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| 引用本文： | 李廷钊,张卫东,顾正兵,刘文庸,周静,陈万生. 糙叶败酱中木脂素成分研究糙叶败酱中木脂素成分研究[J]. 药学学报, 2003, 38(7): 520-522 |
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| 作者姓名： | 李廷钊 张卫东 顾正兵 刘文庸 周静 陈万生 |
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| 作者单位： | 第二军医大学药学院 上海长征医院药剂科 第二军医大学药学院 上海 |
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| 摘 要： | 目的研究糙叶败酱（Patrinia scabra Bge.）中的木脂素类化学成分。方法应用柱色谱HPLC法分离纯化，通过光谱（IR，MS，1HNMR，13CNMR，DEPT，HMQC和HMBC）鉴定其化学结构。结果和结论分离并鉴定了4个木脂素类化合物，分别鉴定为：落叶松脂醇(1)，4-［1-乙氧基-1-(4′-羟基-3′-甲氧基)苯基］甲基-2-(4-羟基-3-甲氧基)苯基-3-羟甲基四氢呋喃(2)，异落叶松树脂酚(3)，去甲络石糖苷(4)。化合物2为新的木脂素，化合物3，4为首次从该属植物中分得。
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| 关 键 词： | 糙叶败酱 木脂素 4-［1-乙氧基-1-(4′-羟基-3′-甲氧基)苯基］甲基-2-(4-羟基-3-甲氧基)苯基-3-羟甲基四氢呋喃 |
| 收稿时间： | 2002-09-15 |
Studies on the lignans from Patrinia scabra |
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| LI Ting-zhao,ZHANG Wei-dong,GU Zheng-bing,LIU Wen-yong,ZHOU Jing,CHEN Wan-sheng. Studies on the lignans from Patrinia scabra[J]. Acta pharmaceutica Sinica, 2003, 38(7): 520-522 |
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| Authors: | LI Ting-zhao ZHANG Wei-dong GU Zheng-bing LIU Wen-yong ZHOU Jing CHEN Wan-sheng |
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| Affiliation: | School of Pharmacy, Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | Aim To study the lignans from Patrinia scabra Bunge. Methods The constituents were separated and purified by column chromatography with silical gel, RP-silical gel and Sephadex LH-20. Their structures were identified on the basis of spectral data (IR, MS, 1HNMR, 13 CNMR, HMQC and HMBC). Results and Conclusion A new lignan was obtained and its structure was elucidated as 4-[1-ethoxyl-1-(4-hydroxy-3-methoxy)benzyl]methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyl-tetrahydro-furan (2), along with three known lignans, lariciresinol (1),isolariciresinol (3) and nortracheloside (4). |
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| Keywords: | Patrinia scabra Bge. Lignan 4-[1-ethoxyl-1-(4-hydroxy-3-methoxy)benzyl]methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyl-tetrahydro-furan |
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