石胆草中苯乙醇苷的分离与结构鉴定石胆草中苯乙醇苷的分离与结构鉴定

目的 研究石胆草(Corallodiscus flabellata)的化学成分。方法 利用大孔吸附树脂、Sephadex LH-20、硅胶柱色谱进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果分离并鉴定了3个新的苯乙醇苷类化合物,经光谱鉴定化合物的结构为:3,4-二羟基苯乙醇-8-O-［β-D-芹糖基(1→3)］-β-D-葡糖苷(I),3,4-二羟基苯乙醇-8-O-［4-O-咖啡酰基-β-D-芹糖基(1→3)-β-D-葡糖基(1→6)］-β-D-葡糖苷(II),3,4-二羟基苯乙醇-8-O-［β-D-芹糖基(1→3)-β-D-葡糖基(1→6)］-β-D-葡糖苷(III)。结论I,II和III均为新化合物。

Isolation and structural identification of phenylethanoid glycosides from Corallodiscus flabellata

AIM: To study the chemical constituents from Corallodiscus flabellata. METHODS: The compounds were isolated and purified by macroporous adsorption resin, silica gel column chromatography and identified on the basis of their physiochemical and spectral data. RESULTS: Three phenylethanoid glycosides (I-III) were obtained from the n-BuOH fraction of water-extracts. Their structures were elucidated as 3,4-dihydroxyphenylethanol-8-O-beta-D-apiofuranosyl (1-->3)]-beta-D-glucopyranoside (I), 3,4-dihydroxyphenylethanol-8-O-4-O-trans-caffeoyl-beta-D-apiofuranosyl (1-->3)-beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside (II) and 3,4-dihydroxyphenylethanol-8-O-beta-D-apiofuranosyl(1-->3)-beta- D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside (III). CONCLUSION: Compounds I, II and III are new compounds.