| 蛇床子素在兔体内药物代谢动力学 |
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| 引用本文： | 安芳,王书华,张丹参,张力,穆金秀. 蛇床子素在兔体内药物代谢动力学[J]. 药学学报, 2003, 38(8): 571-573 |
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| 作者姓名： | 安芳 王书华 张丹参 张力 穆金秀 |
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| 作者单位： | 张家口医学院,化学、药理教研室,河北,张家口,075029 |
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| 基金项目： | 河北省科技攻关项目 (d0 0 2 7614 7) |
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| 摘 要： | 目的研究蛇床子素在兔体内的药物代谢动力学。方法用高效液相色谱法,以丹皮酚为内标,以甲醇-水(80∶20)为流动相,测定兔血液中蛇床子素(iv,10 mg·kg-1)的含量。采用3P87程序计算药物代谢动力学参数。结果蛇床子素iv药代动力学符合二房室开放模型,T1/2α=5.81 min,T1/2β=42.2 min,K21=0.036 0·min-1,K12=0.045 0·min-1,K10=0.054 0·min-1,AUC=235 mg·min·L-1,CLs=0.043 0 L·min-1·kg-1,VC=0.780 L·kg-1。结论蛇床子素在兔体内分布及消除较快
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| 关 键 词： | 蛇床子素 药代动力学 高效液相色谱 血药浓度 |
| 收稿时间： | 2002-08-30 |
Pharmacokinetics of osthole in rabbits |
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| AN Fang,WANG Shu-hua,ZHANG Dan-shen,ZHANG Li,MU Jin-xiu. Pharmacokinetics of osthole in rabbits[J]. Acta pharmaceutica Sinica, 2003, 38(8): 571-573 |
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| Authors: | AN Fang WANG Shu-hua ZHANG Dan-shen ZHANG Li MU Jin-xiu |
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| Affiliation: | Department of Chemistry and Pharmacology, Zhangjiakou Medical College, Zhangjiakou 075029, China. |
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| Abstract: | AIM: To investigate the pharmacokinetics of osthole in rabbits and obtain the main pharmacokinetic parameters. METHODS: A simple high-performance liquid chromatography (HPLC) method was developed to study the pharmacokinetics of osthole in rabbits by joining an internal standard (paeonal). Methanol-water (80:20) was used as the mobile phase. According to the 3P87 pharmacokinetic program, the main parameters were calculated. RESULTS: The osthole pharmacokinetics conforms to a two compartment open model after i.v. administration, T1/2 alpha = 5.81 min, T1/2 beta = 42.2 min, K21 = 0.036 0.min-1, K12 = 0.045 0.min-1, K10 = 0.054 0.min-1, AUC = 235 mg.min.L-1, CLs = 0.043 0 L.min-1.kg-1, Vc = 0.780 L.kg-1. CONCLUSION: The pharmacokinetics of osthole after i.v. administration showed a rapid distribution and elimination process in rabbits. |
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| Keywords: | osthole pharmacokinetics HPLC plasma concentration |
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