|
|||||
|
|
| 噻唑烷二酮类降糖药物与骨质疏松症 | |
| 引用本文： | 盛辉,李文君,盛春君,秦岭,王洪复,曲伸,吴国亭.噻唑烷二酮类降糖药物与骨质疏松症[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(2):113-115. |
| 作者姓名： | 盛辉 李文君 盛春君 秦岭 王洪复 曲伸 吴国亭 |
| 作者单位： | 1. 同济大学附属第十人民医院内分泌与代谢病科,上海,200072 2. 香港中文大学矫形外科与创伤学系骨肌肉关节研究中心,香港,999077 3. 复旦大学放射医学研究所骨代谢研究室,上海,200032 |
| 基金项目： | 国家自然科学基金，教育部博士点基金，上海市浦江人才计划，同济大学附属第十人民医院优秀青年人才计划项目 |
| 摘 要： | 噻唑烷二酮类降糖药物因能改善胰岛素抵抗，临床广泛用于2型糖尿病、多囊卵巢综合征及非酒精性脂肪肝的治疗。最近研究结果提示，噻唑烷二酮类降糖药物在改善胰岛素抵抗降血糖的同时，可提高骨质疏松症及骨质疏松骨折的风险。本文综述了噻唑烷二酮类降糖药物致骨丢失的相关证据和增加骨质疏松症及骨质疏松骨折风险的可能病理机制，并探讨其临床防治策略。 |
| 关 键 词： | 噻唑烷二酮 骨质疏松症 |
Thiazolidinediones and Osteoporosis |
|
| Institution: | SHENG Hui, LI Wen-jun , SHENG Chun-jun, et al (1. Department of Endocrinology and Metabolism, Shanghai l Oth People＇s Hospital, Tongfi University School of Medicine, Shanghai 200072 ; 2. Mnsculoskeletal Research Laboratory of Department of Orthopaedics ＆ Traumatology, the Chinese University of Hong Kong, Hong Kong SAR, Hong Kong 999077 ; 3. Laboratory of Bone Metabolism, the Institute of Radiation Medicine, Fudan University, Shanghai 200032, China) |
| Abstract: | Thiazolidinediones （TZDs）, as insulin sensitizers, are widely used for treatment of type 2 diabetes mellitus, polycystic ovary syndrome and non-alcoholic fatty liver. Recent studies indicated that TZDs could increase the risk of osteoporosis and ostoeporotic fractures. This paper reviewed the evidences that TZDs caused bone loss in clinical and animal studies, its possible mechanisms and corresponding prevention and treatment strategies. |
| Keywords: | thiazolidinediones osteoporosis |
| 本文献已被 维普 万方数据 等数据库收录！ | |