| 蝎毒抗癌多肽对人肝癌细胞株的作用 |
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| 引用本文： | 魏玲,孔天翰,董伟华.蝎毒抗癌多肽对人肝癌细胞株的作用[J].肿瘤防治研究,2002,29(1):9-11. |
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| 作者姓名： | 魏玲 孔天翰 董伟华 |
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| 作者单位： | 1. 山东省肿瘤防治研究中心实验室,济南,250117
2. 河南医科大学生物毒素中心 |
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| 基金项目： | 河南省“九五”科技攻关项目（951200102） |
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| 摘 要： | 目的 观察蝎毒抗癌多肽（ＡＰＢＭＶ）对人肝癌细胞ＳＭＭＣ－７７２１的作用。方法ＭＴＴ法、生长抑制实验和集落形成实验。结果 ＡＰＢＭＶ对 ＳＭＭＣ－７７２１细胞具较强毒性作用，ＩＣ５０为１１．３３μｇ／ｍｌ；ＡＰＢＭＶ可显著抑制细胞生长，剂量与时间效应关系明显。结论ＡＰＢＭＶ是东亚钳蝎蝎毒中有效低毒的抗肿瘤成分，对肝癌细胞有一定的毒性作用。
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| 关 键 词： | 蝎毒 肝癌 细胞株 多肽 |
| 文章编号： | 1000-8578(2002)01-0009-03 |
| 收稿时间： | 2001-3-2 |
| 修稿时间： | 2001-5-28 |
The effect of APBMV on human hepotoma cell line |
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| WEI Ling,KONG Tian-han,DONG Wei-hua.The effect of APBMV on human hepotoma cell line[J].Cancer Research on Prevention and Treatment,2002,29(1):9-11. |
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| Authors: | WEI Ling KONG Tian-han DONG Wei-hua |
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| Institution: | Shandong Tumor Hospital &; Institute; Ji nan 250117; China |
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| Abstract: | Objective To obserne the effect of antineoplastic polypeptide from Buthus martensii venom (APBMV) on the human heptoma cells SMMC-7721. Methods Using the MTT colorimetric method, the growth-inhibiting test and the colony-formation inhibiting assay. Results The results revealed that APBMV had obvious cytotoxicity on SMMC-7721,1C50 was 11. 33μg/ml;APBMV could obviously inhibit the cellu- lar growth. There were obvious dose-response and timeresponse relationship. The IC50 we... |
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| Keywords: | Scorpion venom Liver neoplasm Cell line Polypeptide |
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