PET/CT 18F-FDG最大标准化摄取值对肺癌的诊断价值

[目的]探讨肺部病灶18F-FD GPET/CT最大标准化摄取值(SUVmax)与病灶短径以及肺癌病理类型之间的相关性,以评估SUVmax诊断肺癌的价值.[方法]回顾性分析2010年7月至2012年2月127例行18-FD GPET/CT显像的肺部占位患者,在PET/CT图像上测算肺部病灶的SUVmax值及最短径,并进行统计学分析.[结果]肺癌组和良性组的短径与SUVmax之间分别均呈正相关；肺癌组与良性组的SUVmax存在统计学差异(P=0.0002),但两组短径无统计学差异(P=0.0938)；鳞癌组与腺癌组的短径存在统计学差异(P=0.0059)；非小细胞肺癌组和小细胞肺癌组之间的SUVmax及短径均无统计学差异(P=0.8932;P=0.6355).[结论]18F-FDG PET/CT SUVmax可以作为肺部病灶良恶性诊断的有效指标,有助于肺部病灶的诊断和鉴别诊断.

The Value of the Maximum Standardized Uptake Value(SUVmax) of 18F-FDG PET/CT in the Diagnosis for Lung Cancer

[Purpose] To evaluate the correlations of the maximum standardized uptake value（SUVmax） of 18 F-FDG PET/CT and the short diameters of pulmonary lesions with the pathological types of lung cancer,and to assess the feasibility of using SUVmax as an important evaluation parameter for lung cancer diagnosis.[Methods] One hundred twenty-seven cases with clinically suspected lung cancer undergoing 18 F-FDG PET/CT from July 2010 to February 2012,were retrospectively reviewed.All PET/CT images were analyzed visually and semiquantitatively by 2 physicians.In each case,the SUVmax and the short diameter of the lesions were calculated from the PET/CT images.All data were analyzed by statistical software.[Results] Positive correlation of the SUVmax and short diameter of the lesions in malignant group or benign group was found.A significant difference of SUVmax between malignant group and benign group was observed（P=0.0002）,but not of the short diameters of the lesions（P=0.0938）.The short diameter of squamous cell carcinoma group was significantly different from that of adenocarcinoma group（P=0.0059）.However,there was no significant differences of SUVmax or short diameters between non-small cell lung cancer（NSCLC） group and small cell lung cancer group respectively（P=0.8932 and P=0.6355）.[Conclusion] 18 F-FDG PET/CT SUVmax might be used as an important parameter to differentiate malignant tumors from benign ones,contributing to the diagnosis and differential diagnosis for pulmonary lesions.