肝内胆管细胞癌根治术的预后因素分析

目的]分析影响肝内胆管细胞癌(IHC)根治术预后的因素.方法]回顾性分析82例IHC患者的临床及病理资料,阅读病理切片,寻找显微镜下是否存在微转移灶.对所有患者进行定期随访,并行生存分析.结果] 82例IHC手术切除标本中,53例(64.6％)显微镜下可见微转移灶.存在微转移灶、γ-谷氨酰转肽酶(γ-GT)高、癌胚抗原(CEA)增高及有肝内结石或血吸虫等慢性肝病史是IHC的独立预后因素.结论]镜下存在微转移灶、CEA增高、慢性肝病史、γ-GT升高是根治性切除后的IHC独立不良预后因素,根治术后应积极治疗.

Analysis of Prognostic Factors of Intrahepatic Cholangiocarcinoma After Radical Surgery

Purpose] To investigate the prognostic factors of intrahepatic cholangiocarcinomas（I-HC） after radical surgery.Methods] Eighty-two cases with IHC proven pathologically after radical surgery were enrolled.The micro-metastasis was found with microscope.All the patients were fol-lowed up.SPSS 17.0 was used for statistic analysis.Results] Fifty-three（64.6%） IHC patients had micro-metastasis.Both univariate analysis and multivariate analysis showed that micro-metastasis,intrahepatic calculi or liver fluke and serum higher γ-GT and CEA were independent prognostic factors（P 0.05）.Conclusion] Micro-metastasis,intrahepatic calculi or liver fluke and serum higher γ-GT and CEA are independent prognostic factors of IHC after radical surgery,and new treatment strategy should be made accordingly.