入骨髓核分化抗原在骨肉瘤中的表达及临床意义

[目的]探讨人骨髓核分化抗原(MNDA)在骨肉瘤中的表达及临床意义.[方法]采用免疫组化法检测MNDA在20例骨软骨瘤和42例骨肉瘤组织中的表达,并分析MNDA表达程度与年龄、性别、病理类型和复发、转移等因素的关系.[结果]MNDA在骨肉瘤组的阳性表达率(17％)明显低于骨软骨瘤组(80％)(P＜0.01).MNDA的阳性表达与性别、年龄无关(P＞0.05),与骨肉瘤的病理类型及是否有复发转移相关.[结论]MNDA在骨肉瘤中低表达,为干扰素在骨肉瘤中的研究提供了理论依据.

Expression and clinical significance of myeloid nuclear differentiation antigen in osteosarcoma

[Objective]To investigate the expression of myeloid nuclear differentiation antigen(MNDA) in osteosarcoma and analyse its clinical significance in osteosarcoma.[Methods]Immunohistochemical staining was used to detect the expression of MNDA in 42 cases of osteosarcoma and 20 cases of osteochondroma as matched control.[Results]In 42 cases of osteosarcoma,7 were positive for MNDA,and the positive rate was 17%.There was significant difference between osteosarcoma and osteochondroma in MNDA positive expression(P<0.01).The expression of MNDA was related to pathological type,recurrence and metastasis of osteosarcoma,and had no relation to other clinical characteristics,such as patient age and gender.[Conclusion]Low expression of MNDA is found in osteosarcoma,and it provides a basis for the using of interferon in the treatment of osteosarcoma and the study of its anti-tumor mechanism.