2型糖尿病合并亚甲减患者血脂和甲状腺激素相关性的临床研究

目的探讨2型糖尿病（DM2）合并亚甲减患者血脂和甲状腺激素（TH）的相关性。方法采用生化法和电化学发光免疫分析测定了568例DM2非亚甲减组的空腹血糖（FBG）、糖化血红蛋白（HbA1c）、血脂（TC、TG、HDL-C、LDL-C、Lp（a））和甲状腺激素（FT3、FT4、TSH），并与51例DM2合并亚甲减组进行了对比性分析。结果DM2非亚甲减组FBG和HbA1c水平较之DM2亚甲减组无明显差异（P均〉0．05）；DM2非亚甲减组血清HDL-C和LDL-C较之DM2亚甲减组无明显差异（P均〉0．05）；DM2亚甲减组血清TC、TG和Lp（a）水平较之DM2非亚甲减组明显增高（P均〈0．05）；DM2非亚甲减组血清FT3和FT4水平较之DM2亚甲减组无明显差异（P均〉0．05），而DM2亚甲减组血清TSH水平较之DM2非亚甲减组明显增高（P〈0．01）。结论DM2合并亚甲减并非少见，应该定期进行血脂和甲状腺功能检查，以便早诊断和及时治疗，从而预防和延缓甲减及缺血性心脏病的发生。

Clinical Study on Correlativity of Determining Blood Lipid and Thyroid Hormone in Patients with Type 2 Diabetes Mellitus with Subclinical Hypothyroidism

Objective To explore the correlativity of determining blood lipid and thyroid hormone in patients with type 2 diabetes mellitus with subclinical hypothyroidism.Methods The fasting blood glucose（FBG）,HbAlc,blood lipid（TC,TG,HDL-C,LDL-C and Lp（a））（with biochemistry method） and thyroid hormone（FT3,FT4 and TSH）（with electrochemiluminescence immunoassay） levels were determined in 568 patients with type 2 diabotes mellitus（DM2） without subclinical hypothyroidism group and in 51 patients with DM2 with subclinical hypothyroidism group with a comparison study.Results The FBG and HbAlc levels in 568 patients with DM2 without subclinical hypothyroidism group were not significantly different from those in 51 patients with DM2 with subclinical hypothyroidism group（P all 〉 0.05）.In blood lipid analysis,serum HDL-C and LDL-C levels in 568 patients with DM2 without subclinical hypothyroidism group were not significantly different from those in 51 patients with DM2 with subclinical hypothyroidism group（P all 〉 0.05）,but serum TC,TG and Lp（a） levels in 51 patients with DM2 with subclinical hypothyroidism group were significantly higher（P all 〈 0.05）. In TH analysis,serum FT3 and FT4 levels in 568 patients with DM2 without subclinical hypothyroidism group were not significantly different from those in 51 patients with DM2 with subclinical hypothyroidism group（P all 〉 0.05）,but serum TSH level in 51 patients with DM2 with subclinical hypothyroidism group was significantly higher（P 〈 0.01）.Conclusion The patients with DM2 with subclinical hypothyroidism were not a few and should be done blood lipid and thyroid function examination by period,so as to get early diagnosis and treatment,to prevent and delay clinical hypothyroidism and ischemic cardiovascular diseases.