IGF-1在胃癌组织中的表达及其与浸润转移的关系

目的]探讨胃癌中IGF-1蛋白的表达及其与肿瘤浸润转移的关系。方法]免疫组织化学技术分析436例胃癌组织及92例邻近正常胃黏膜组织石蜡标本中IGF-1的表达。结果]IGF-1在正常胃黏膜组织的表达低于胃癌组织(0 vs 49.5%,χ2=77.132,P<0.001);IGF-1表达与胃癌患者肿瘤大小、分化、侵犯深度、分期、淋巴结转移、远处转移、脉管侵犯、Lauren分型相关,而与组织学类型、性别无关。胃癌患者中肿瘤大小≥5cm患者的IGF-1阳性表达率为64.4%,明显高于<5cm的患者(39.1%,χ2=27.238,P<0.001);弥漫型胃癌患者IGF-1的阳性表达率明显高于肠型患者(85.0%vs 15.7%,χ2=209.184,P<0.001);T3、T4期胃癌患者的IGF-1阳性表达率分别为62.7%、92.3%,明显高于T1、T2期的10.5%、30.3%(χ2=86.830,P<0.001);脉管侵犯患者的IGF-1阳性表达率明显高于无脉管侵犯者(71.5%vs 19.1%,χ2=116.710,P<0.001);淋巴结转移患者的IGF-1阳性表达率为70.0%,明显高于无淋巴结转移者(16.3%,χ2=118.740,P<0.001);远处转移患者的IGF-1阳性表达率为95.1%,明显高于无远处转移者(42.1%,χ2=58.841,P<0.001)。结论]IGF-1与胃癌的发生发展有关,参与胃癌的浸润转移进程。检测IGF-1的表达可作为判断胃癌生物学行为的重要参考指标。

Expression of IGF-1 in Gastric Cancer and Its Relationship with Cancer Invasion and Metastasis

Purpose] To investigate the expression of IGF-1 and its relationship with invasion and metastasis in gastric cancer.Methods] IGF-1 expression in sample tissues of 436 cases with gastric cancer and 92 cases of cancer adjacent gastric mucosa was detected immunohistochemically.Results] IGF-1 expression in cancer adjacent gastric mucosa was significantly lower than that in gastric cancer tissues（0 vs 49.5%,χ2= 77.132,P0.001）.IGF-1 expression was related to tumor size,differentiation,depth of invasion,stage,lymph node metastasis,distant metastasis,vascular invasion,Lauren classification of gastric cancer,except the histologic type and gender.IGF-1 positive expression rate in gastric cancer patients with tumor size≥5cm（64.4%） increased significantly than that in patients with tumor size 5cm（39.1%,χ2= 27.238,P0.001）.IGF-1 positive expression rate in patients with diffusing type cancer（85.0%） increased significantly than that in intestinal-type cancer（15.7%,χ2=209.184,P0.001）.IGF-1 positive expression rate in patients stage T3 and T4（62.7% and 92.3%） increased significantly than that in T1 and T2 stage patients（10.5% and 30.3%,χ2=86.830,P0.001）.IGF-1 positive expression rate in patients with vascular invasion（71.5%） increased significantly than that in patients without vascular invasion（19.1%,χ2=116.710,P0.001）.IGF-1 positive expression rate in patients with lymph node metastasis（70.0%）increased significantly than that in patients without lymph node metastasis（16.3%,χ2=118.740,P0.001）.IGF-1 positive expression rate in patients with distant metastasis（95.1%） increased significantly than that in patients without distant metastasis（42.1%,χ2=58.841,P0.001）.Conclusion] IGF-1 relates to the carcinogenesis of gastric cancer,and involves in the process of invasion and metastasis of gastric cancer.IGF-1 expression could be used as an important reference indicator for biological behavior for gastric cancer.