引起急性腹泻的两种变形杆菌的耐药性分析

目的 了解引起急性腹泻的普通变形杆菌与奇异变形杆菌种类特征，耐药性与其菌种的关系。方法 对2002年9月～2004年9月急性腹泻病人粪便中分离的奇异变形杆菌127株，普通变形杆菌30株进行鉴定。采用纸片扩散法进行药敏试验。结果 普通变形杆菌对阿米卡星、头孢哌酮、头孢他定、头孢吡肟。亚胺培南耐药率在20％以下，可作为经验首选药物，对氨苄青霉素、头孢噻吩为100％耐药。但奇异变形杆菌对抗生素敏感性好，氨苄青霉素，头孢噻吩耐药率在23％以下。结论 两种变形杆菌对抗生素的耐药性有较大区别，治疗时可根据菌种选择抗生素，同时，通过某些药敏试验结果还可以协助菌种鉴定。

Drug Resistance Analysis of Two Proteus strains That Cause Acute Diarrhea

Objective To study the characteristics and drug resistance ofP. vulgaris and P. mirabilis that can cause acute diarrhea. Methods 127 strains of P. mirabilis and 30 strains of P. vulgaris which had been isolated from acute diarrhea patients from Sept. 2002 to Sept. 2004. The isolated strains were identified and tested for antimicrobial drug resistance using disc diffusion method. Results The resistant rates of P. vulgaris to amikacin, cefoperazone,ceftazidime, cefepine, lmipenem were all below 20%. These antibiotics should be the first choice for treating the disease. The resistant rate of P. vulgaris to ampicillin was 100%. The resistant rates of P. mirabilis for ampicillin and cefalothin were all bellow 23%. Conclusion There was a noticeable difference between the two species of Proteus. The antibiotics should be selected for treatment according to the can be selected according to the species of the bacteria.Drug resistance test may help us to identify the species.