血清降钙素原与超敏C反应蛋白联合检测在脓毒症诊断中的意义

目的：测定血清降钙素原（procalcitonin,PCT）与超敏C反应蛋白（high-sensitive C-reactive protein,hs-CRP）的含量,探讨其在脓毒症诊断中的应用价值.方法：选取2012年1月至2013年4月沈阳医学院附属中心医院重症监护病房的脓毒症患者32例和非脓毒症患者40例,同期健康体检人员20例,分别检测血清PCT及hs-CRP水平.比较PCT、hs-CRP及PCT＋ hs-CRP在诊断脓毒症中的敏感性与特异性.结果：与健康体检人群及非脓毒症患者比较,脓毒症患者血清PCT与hs-CRP水平均显著升高（P＜0.01）.在诊断脓毒症感染中,PCT、hs-CRP及PCT＋ hs-CRP的敏感性分别为87.5％、96.9％和96.9％,特异性分别为80.0％、35.0％和82.5％.结论：血清PCT和hs-CRP水平的检测有助于脓毒症的早期诊断及鉴别诊断,并可作为判断预后的指标.二者联合检测可提高脓毒症诊断的可靠性.

The Clinical Significance of Combination Detection of Procalcitonin with High-sensitive C-reactive Protein

Objective： To investigate the value of serum procalcitonin （PCT） and high-sensitive C-reactive protein （hs-CRP） in diagnosis of sepsis. Methods： The patients were selected from intensive care unit of The Central Hospital Affiliated to Shenyang Medical College, including 32 patients with sepsis and 40 patients with non-sepsis and 20 health people were selected as control group. The serum PCT and hs-CRP level was detected respectively. The sensitivity and specificity of PCT, hs-CRP were compared with that of combination detection of PCT with hs-CRP. Results： The serum PCT and hs-CRP level of sepsis group was higher than that of non-sepsis group and control group （P 〈 0. 01 ）. In diagnosis of sepsis, the sensitivity of serum PCT, hs-CRP and combina- tion of PCT and hs-CRP was 87. 5%, 96. 9% and 96.9%, the specificity was 80. 0%, 35.0% and 82. 5%. Conclusions： The detection of serum PCT and hs-CRP is helpful to early diagnosis and differential diagnosis of sepsis, and can be used as a prognostic indicator. The combination detection of serum PCT with hs-CRP can increase reliability in diagnosis of sepsis.