两种下腔静脉滤器的体内血液相容性评价

目的在动物体内评价一种新的下腔静脉滤器（X滤器）和Cordis下腔静脉滤器（C滤器）的血液相容性。方法实验动物为8头猪，雄性，体质量（30±5）kg。将X和C两种滤器置入动物的下腔静脉（肾静脉开口下缘），在不给动物服用抗凝药物的情况下观察14d，然后取出滤器观察血栓形成情况，对其输送系统进行电镜观察，并在置入滤器前和取出滤器前分别对动物进行造影观察和白细胞、血小板的检测。结果两种滤器对白细胞和血小板都没有明显影响，X滤器和C滤器置入前和取出前白细胞平均值的变化分别是（0．575±4．333）×10^9／L、（3．375±9．411）×10^9／L，P〉0．05；血小板平均值变化分别是（-0．500±57．190）×10^9／L、（-33．000±57．860）×10^9／L。电镜观察显示两种滤器的输送系统都无血栓形成，但是造影显示X滤器血流有不同程度受阻，而C滤器血流受阻不明显；X滤器内有大量血栓形成，而C滤器内没有。结论C滤器的血液相容性好于X滤器。

In vivo hemocompatibility evaluation in two kinds of inferior vena cava filters

Objective To evaluate the hemocompatibility of a new inferior vena cava filter （X filter） and the Cordis inferior vena cava fiher（C filter）. Methods Eight male pigs, （30 ± 5 ） kg wt were adopted as the experimental animal. The X and C filters were implanted into animal＇s vena cava inferior（at the margin of renal vein opening） without using any anticoagulants and followed-up 14 days. Then withdrew the filters and observed thrombosis on them. The filter transmission system was observed by scanning electron microscopy（SEM）. Before implanting and withdrawing the filter, cavography was performed respectively, WBC and platelet count were detected. Results The results showed that the X and C filters didn＇ t significantly affect the WBC and platelet count. The average change of WBC was （0.575 ±4.333）×10^9 in X filters and （3.375 ±9.411 ） ×10^9 in C filters, and the average change of PLT was（-0.500 ± 57.190） ×10^9 in X filters and （-33.000±57.860）×10^9in C filters. No thrombosis was found in both filter transmission systems by SEM study. The result of cavography showed that the blood flow in X filters was blocked in different intensities but the blood flow was not affected in C filters. Thrombosis was serious in the X filters, but was not found in C filters. Conclusion It is demonstrated that the hemocompatibility of C filter is superior to X filter.