| 凋亡抑制因子Survivin与肿瘤诊治的研究进展 |
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| 引用本文： | 伊新,曲喜英,林木生. 凋亡抑制因子Survivin与肿瘤诊治的研究进展[J]. 中国癌症杂志, 2003, 13(2): 182-185 |
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| 作者姓名： | 伊新 曲喜英 林木生 |
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| 作者单位： | 1. 广东医学院附属医院肝胆外科,广东,湛江,524001
2. 广东医学院生物化学与分子生物学研究所,广东,湛江,524023 |
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| 摘 要： | Survivin属凋亡抑制蛋白家族新成员，具有抑制细胞凋亡和调节细胞分裂的双重功能；Survivin是肿瘤特异性凋亡抑制因子，高表达于多种肿瘤组织而在正常成人组织中未见表达。研究表明，Survivin在肿瘤的发生、发展过程中起关键作用，是估计肿瘤预后和复发的重要指标。Survivin还参与血管形成过程。近来，Survivin已成为肿瘤诊断、治疗的新靶点。
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| 关 键 词： | 抑制因子 Survivin 肿瘤 研究进展 细胞凋亡 细胞分裂 血管形成 基因治疗 |
| 文章编号： | 1007-3639(2003)02-0182-04 |
| 修稿时间： | 2002-05-27 |
Advances in research on Survivin ,the inhibitor of apoptosis in cancer diagnosis and therapy |
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| YI Xin,Qu Xi ying,LIN Mu sheng. Advances in research on Survivin ,the inhibitor of apoptosis in cancer diagnosis and therapy[J]. China Oncology, 2003, 13(2): 182-185 |
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| Authors: | YI Xin Qu Xi ying LIN Mu sheng |
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| Abstract: | WTBZ]Survivin belongs to the member of IAP family (inhibitor of apoptosis, IAP) proteins and is a bifunctional protein that suppresses apoptosis and regulates cell division. Survivin is a tumor specific antiapoptosis factor that is expressed selectively in all the most common human carcinomas but not in normal adult tissues. Studies indicated that Survivin played a crucial role in the genesis and progression of malignancy and was an important predictive/prognostic parameter in tumors. Survivin also participates in angiogenesis. Recently, Survivin has been used as a novel diagnostic/therapeutic target in cancer. |
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| Keywords: | survivin apoptosis cell division angiogenesis molecular diagnosis gene therapy |
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