β-hCG、Uric Acid和ET含量与妊高征疾病程度的关系

目的评价妊高征患者血中β绒毛膜促性腺激素、尿酸和内皮素的水平及其关系。探讨B—hCG、Uric Acid和ET在妊高征发病中的作用。方法按标准将70例妊高征分为：轻度35例，重、中度35例。另选正常中晚期妊娠妇女30例；β—hCG测定采用化学发光法；尿酸测定采用生化分析法；ET采用放射免疫测定法。结果重、中度妊高征组ET、β-hCG和Uric Acid含量均高于正常中晚期妊娠组（P均〈0．05～0．01）；轻度妊高征组血浆ET和β-hCG水平与正常中晚期妊娠组无显著性差异（P〉0．05）；Uric Acid水平高于正常中晚期妊娠组（P〈0．05）；重、中度妊高征组ET、β-hCG和Uric Acid水平均高于轻度妊高征组（P〈0．05）；重、中度妊高征组血中ET、β—hCG和Uric Acid呈正相关（r=0．5713，r=0．5688，r=0．5849，P均〈0．05）；而轻度妊高征组和正常晚期妊娠组血中ET和β—hCG变化无显著性相关（P〉0．05）。血清尿酸水平与血压仅有较弱的相关性（r=0．2313）。结论重、中度妊高征血管内皮细胞损伤可能与胎盘滋养细胞功能失调相关。尿酸水平可以作为判断高血压孕妇是否合并妊高征的监测方法之一。

The Relationship Between Contents of ET,Uric acid,β-hCG and Degree of Disease in Patients with Pregnancy Induced Hypertension

Objective To evaluate levels of endothelin（ET）and β-human chorionic gonadotropin（ β-hCG） and the relationship between them in patients with pregnancy induced hypertension（PIH）, and to investigate the role of ET and β-hCG in the pathogenesis of PIH. Methods By standard methods will be 70 cases of pregnancy-induced hypertension,divided into：35 cases of patients with Light degree,and 35 cases of Moderate, severe degree pregnancy-induced hypertension, 30 cases normal women in late pregnancy; β-hCG determined by chemiluminescence method;Uric acid determined by biochemical analysis methods;ET by radioimmunoassay method. Results The contents of ET, β-hCG and Uric Acid in heavy,moderate PIH group were higher than normal were higher than in late pregnancy group（P〈 0.05-0.01 ）;The contents of ET and β-hCG in light degree group and normal in late pregnancy was no significant difference（P 〉 0.05 ）. The contents of Uric Acid higher than normal in late pregnancy（P〈 0.05） ;The contents of ET, β-hCG and Uric Acid in heavy,moderate PIH group higher than the light degree group（P〈 0.05）. The contents of ET, β-hCG and Uric Acid were positively correlated in heavy,moderate PIH group（r = 0.5713, r = 0.5688, r = 0.5849, P 〈 0.05 ）;The contents of ET and β-hCG were no correlated in light degree group and normal in late pregnancy（P〉 0.05）; Serum uric acid levels and blood pressure only weak correlation（r = 0.2313）. Conclusion The vascular endothelial cell injury and placental trophoblast cells may dysfunction related in heavy, moderate PIH. Uric acid levels can be used as a hypertensive pregnant women to merge one of the methods of monitoring pregnancy-induced hypertension.