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Low-mannose-binding lectin levels in susceptibility to neonatal sepsis in preterm neonates with fetal inflammatory response syndrome
Abstract:Aim.?In this study, we aimed to evaluate cord blood mannose binding levels (MBL), to evaluate possible relationship between cord blood MBL levels with neonatal sepsis and culture confirmed neonatal sepsis in preterm newborn with gestational age below 34 weeks with fetal inflammatory response syndrome (FIRS).

Methods.?Forty-four randomly selected ≤34 weeks gestational age newborns with FIRS were evaluated. MBL deficiency was described as cord blood levels were below 400?ng/ml.

Results.?Mean value of umbilical cord MBL was significantly lower in newborns with culture confirmed sepsis (p?p?Conclusion.?Here in, we report firstly lower MBL levels were found related with sepsis in neonates, especially in newborns with culture proven sepsis. Low MBL levels may help to identify neonates with FIRS at high risk of developing sepsis.
Keywords:Fetal inflammation  IL-6  TNF-alfa  MBL  preterm delivery
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