| Abstract: | AbstractContext: Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits.Objective: The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats.Materials and methods: Wistar rats were pretreated orally with three doses of standardized ginger extract (100, 200, and 400?mg/kg of body weight) or propranolol (5?mg/mL) for 28?d prior to ISO (85?mg/kg) induced MI in two doses on days 29 and 30. The rats were sacrificed 48?h after the first induction; serum and hearts were collected for biochemical and histopathological analysis.Results: Gingerols and shogaols were identified and quantitatively analyzed in the extracts using validated reversed phase HPLC methods. Pretreatment with ginger extract at 400?mg/kg showed a significant decrease (p?p?Conclusion: The ethanol extract of ginger exhibited cardioprotective potential in treating myocardial injury following ISO administration. |
