Protective effects of Hammada scoparia flavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Abstract

Context: Hepatic ischemia/reperfusion injury (IRI) is a major cause of liver damage during liver surgery and transplantation. Plants have historically been used in treating liver damage, and Hammada scoparia (Pomel) (Chenopodiaceae) has been reported to possess a broad spectrum of pharmacological and therapeutic activities.

Objective: In this study, a flavonoid-enriched fraction was used before the warm ischemia (WI) process as pharmacological preconditioning and in combination with technical postconditioning to evaluate their protective effects.

Materials and methods: The rats were divided into five groups: a sham group; a control group (Control-IR) that was submitted to 60?min WI; a Pharmacological Preconditioning group (PreC-IR) that received flavonoid-enriched fraction (200?mg/kg body weight); a Postconditioning group (PostC) and a PreC?+?PostC group.

Results: The use of the flavonoid-enriched fraction was noted to significantly (p?Discussion and conclusion: Overall, the results indicate that the H. scoparia flavonoid-enriched fraction could be a promising candidate for future application as a pharmacological preconditioning agent against hepatic IRI.