Houttuynia cordata alleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Abstract

Context: Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms.

Objective: To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis.

Materials and methods: HFD fed rats were orally dosed with HC-EA (100, 200, or 300?mg/kg) once daily for 8?weeks and the lipid profiles and protein expressions in hepatocytes were evaluated.

Results: HFD rats showed an increase (p?p?p?Discussion and conclusion: Data suggest that HC-EA extract might act by regulating the AMPK-dependent pathway and related mediators and might be used in treating obesity-related liver diseases.