| CTOP和CHOP方案治疗外周T细胞淋巴瘤的临床随访分析 |
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| 引用本文： | 余延芳,方志坚,田小园,刘芳,王明迪,李德津.CTOP和CHOP方案治疗外周T细胞淋巴瘤的临床随访分析[J].中国肿瘤临床与康复,2011(4):356-358,361. |
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| 作者姓名： | 余延芳 方志坚 田小园 刘芳 王明迪 李德津 |
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| 作者单位： | 北京大学首钢医院血液内科; |
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| 摘 要： | 目的比较含吡喃阿霉素(THP)的CTOP方案与含阿霉素(ADM)的CHOP方案治疗外周T细胞淋巴瘤(PTCL)的疗效和不良反应。方法回顾性分析外周T细胞淋巴瘤临床特征,比较两种方案的不良反应、近期疗效和远期疗效。结果 29例PTCL中,可行疗效评估的25例,其中CTOP组14例,CHOP组11例;中位随访21.25个月。两组患者临床特征的均衡性比较好。CTOP组和CHOP组的总有效率、完全缓解率分别是78.6%和72.7%(P>0.05)、57.1%和54.5%(P>0.05),3,5年总生存率分别为57.7%和46.3%、32.1%和22.1%(P=0.012),CTOP组有好转趋势。25例患者共接受169个疗程化疗。骨髓抑制为主要不良反应,但两组差异无显著性(P>0.05),CHOP组心脏毒性、脱发、呕吐发生率明显高于CTOP组(P<0.05)。结论采用含THP的CTOP治疗PTCL疗效好,毒性较低,远期生存率较高,尤其对老年PTCL值得临床进一步研究。
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| 关 键 词： | 外周T细胞淋巴瘤 吡喃阿霉素 阿霉素 |
Long-term results of CTOP versus CHOP regimens on peripheral T-cell lymphoma |
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| YU Yan-fang,FANG ZHi-jian,TIAN Xiao-yuan,et al.Long-term results of CTOP versus CHOP regimens on peripheral T-cell lymphoma[J].Chinese Journal of Clinical Oncology and Rehabilitation,2011(4):356-358,361. |
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| Authors: | YU Yan-fang FANG ZHi-jian TIAN Xiao-yuan |
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| Institution: | YU Yan-fang,FANG ZHi-jian,TIAN Xiao-yuan,et al(Department of Haematology,Shou Gang Hosipital,Peking University,Beijing 100144,China) |
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| Abstract: | Objective To compare the efficacy and toxicity of CTOP(with THP)and CHOP(with ADM) in the treatment of peripheral T-cell lymphoma(PTCL).Methods The clinical characteristics of PTCL were reviewed,and the rate of response,toxicity and long-term survival were analysed retrospectively.Results Twenty-five of 29 patients with PTCL could be evaluated,of them,14 were treated with CTOP and 11 with CHOP regimen with a median follow up of 21.25 months.The clinical characteristics of the two groups were similar.The res... |
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| Keywords: | Peripheral T-cell Lymphoma Pirarubicin Adriamycin |
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