脑梗死患者血清C3、C4水平变化及其临床意义

目的观察脑梗死（cerebral infarction，CI）患者血清补体C3、C4水平变化，以探讨其在脑梗死病程中的改变及其临床意义。方法测定43例CI患者急性期和恢复期血浆C3、C4水平，并进行神经功能缺损程度评分（SSS），同时选取同期30例非CI患者为对照组，比较两组患者的C3、C4水平。结果CI组急性期、恢复期及与对照组C3、C4水平间差异均有显著性意义（P〈0．05），且CI患者急性期与对照组C3、C4水平间差异有显著性意义（P〈0．05）。相关分析显示CI患者急性期与恢复期的C4C4水平与SSS评分无关（P〉0．05），而C3与C4则呈正相关（P〈0．05）。结论急性CI的病理过程中存在明显的炎症反应，伴有补体系统的激活和消耗。C3、C4水平与CI的病情无关，提示补体系统激活在脑组织损伤中的作用很可能是间接性的。

Change and Clinical Significance of Plasma C3,C4 in Patients with Cerebral Infarction

Objective To observe the plasma level change of complement C_3,C_4 in patients with cerebral infarction(CI),so as to study the changes and clinical significance of these complements in CI.Methods To mensurate the plasma level of C_3,C_4 in 43 patients with CI in acute period and convalescent period,and to assesses their neurological impairment by the Scandinavian Stroke Scale(SSS) at the same time,then to make comparison with 30 normal controls.Results The concentration of plasma C_3 and C_4 in CI acute group is significant lower than those of controls(P<0.05).The level of plasma C_3 and C_4 of CI convalescent group is up,there was significant difference is observed while compared with the acute group and the control group(P<0.05).Spearman Correlation manifests that the plasma level of C_3 and C_4 have no significant correlation with SSS score(P>0.05) C_3 was positively correlated with C_4(P<0.05).Conclusion The results show that in the pathological mechanism of acute cerebral infarction,there is a evident inflammatory course accompanying the activation and consumption of complement system.The level of C_3 and C_4 have no significant correlation with SSS score,which indicates that the activation of complement probably plays a indirect role in the damage of cerebral tissue.