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Allogenic blood transfusion is an independent risk factor for infective complications after less invasive gastrointestinal surgery
Authors:Ikuta Shin-ichi  Miki Chikao  Hatada Tsuyoshi  Inoue Yasuhiro  Araki Toshimitsu  Tanaka Kouji  Tonouchi Hitoshi  Kusunoki Masato
Affiliation:Second Department of Surgery, Mie University School of Medicine, Edobashi 2-174, Tsu, Japan.
Abstract:BACKGROUND: The present study aimed to clarify the predisposing factors for postoperative infectious complications after less invasive surgery. METHODS: A total 150 surgical patients were placed in either group H (operative blood loss > or = 500 mL) or group L (<500 mL). The patients' background factors and postoperative inflammatory responses were assessed. RESULTS: The operating time was an independent risk factor for infectious complication in group H. In contrast, allogenic blood transfusion was the only significant risk factor for infection in group L. In the patients who received blood transfusion, exaggerated postoperative interleukin-6 response was found in group H, whereas an increased consumption of interleukin-6 soluble receptor with resultant induction of immunosuppressive acidic protein (IAP) were found in group L. CONCLUSIONS: Perioperative blood transfusion may predominantly contribute to increased susceptibility to infection after less invasive surgery through increased affinity of interleukin-6 soluble receptor and enhanced IAP response.
Keywords:Blood transfusion   Postoperative complication   cytokine
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