| 迷走神经刺激对戊四氮致痫大鼠行为及脑电图的影响 |
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| 引用本文： | 樊友武,李龄,刘斌.迷走神经刺激对戊四氮致痫大鼠行为及脑电图的影响[J].华中科技大学学报(医学版),1999(1). |
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| 作者姓名： | 樊友武 李龄 刘斌 |
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| 作者单位： | 同济医科大学附属同济医院外科 |
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| 摘 要： | 为探讨迷走神经刺激（ＶＮＳ）的抗癫痫作用，观察了ＶＮＳ对正常大鼠和戊四氮（ＰＴＺ）致痫大鼠行为和脑电图的影响，结果发现，ＶＮＳ可明显延长致痫大鼠癫痫发作和痫波释放的潜伏期（Ｐ＜０．０５），减轻癫痫发作的严重程度（Ｐ＜０．０１），并能抑制皮层及海马癫痫波的释放（Ｐ＜０．０１），而对正常大鼠脑电图无影响。结果提示ＶＮＳ可明显抑制ＰＴＺ诱导的大鼠癫痫。
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| 关 键 词： | 癫痫 戊四氮 迷走神经刺激 脑电描记术 |
Effect of Vagus Nerve Stimulation on the Behavior and EEG of Pentylenetetrazol induced Seizure in Rats |
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| Fan Youwu,Li Ling,Liu Bin.Effect of Vagus Nerve Stimulation on the Behavior and EEG of Pentylenetetrazol induced Seizure in Rats[J].Journal of Huazhong University of Science and Technology(Health Sciences),1999(1). |
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| Authors: | Fan Youwu Li Ling Liu Bin |
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| Institution: | Fan Youwu,Li Ling,Liu Bin Department of Neurosurgery,Tongji Hospital,Tongji Medical University,Wuhan 430030 |
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| Abstract: | To investigate the effect of vagus nerve stimulation (VNS)in epilepsy, the influences of VNS on the behavior and electroencephalography(EEG) of the normal rats and pentylenetetrazol (PTZ) induced seizure rats were observed The results showed that VNS could obviously prolonged the latency of epileptic attacks and epileptic wave discharge ( P <0 05), reduced the intensity of the seizure ( P <0 01), inhibited epileptic wave discharge( P <0 01) Howerer, VNS had no effect on the EEG of the normal rats The results indicated that VNS can significantly inhibit the PTZ induced seizures of rats |
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| Keywords: | seizure \ vagus nerve stimulation \ electroencephalography \ pentylenetetrazol |
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