| 高温诱导Hep-2细胞凋亡及其对细胞周期进程的影响 |
| |
| 引用本文： | 冯青杰,杜柏山,舒畅,李刚,孙立群. 高温诱导Hep-2细胞凋亡及其对细胞周期进程的影响[J]. 吉林大学学报(医学版), 2004, 30(1): 103-104 |
| |
| 作者姓名： | 冯青杰 杜柏山 舒畅 李刚 孙立群 |
| |
| 作者单位： | 1. 吉林大学第二医院耳鼻咽喉科，吉林 长春130041；2. 吉林大学第二医院麻醉科，吉林 长春130041 |
| |
| 摘 要： | 目的：通过高温诱导Hep-2细胞凋亡探讨细胞凋亡和细胞周期的关系。方法：应用MTT比色法和流式细胞仪检测高温诱导Hep-2细胞凋亡和细胞周期时相的改变。结果：高温组与对照组之间Hep-2细胞凋亡率差异有显著性（P<0.01）。MTT比色法高温组与对照组之间，Hep-2细胞增殖抑制率差异亦有显著性。结论：高温可提高Hep-2细胞的凋亡率，抑制Hep-2细胞的增殖，抑制Hep-2细胞G1期向S期的进程。
|
| 关 键 词： | 生理学 细胞周期 生理学 高温 诱发 |
| 文章编号： | 1671-587X(2004)01-0103-02 |
| 收稿时间： | 2002-08-20 |
| 修稿时间： | 2002-08-20 |
Study on mechanism of Hep-2 cell apoptosis induced by high temperature and its effect on cell cycle progress |
| |
| FENG Qing-jie,DU Bai-shan,SHU Chang,LI Gang,SUN Li-qun. Study on mechanism of Hep-2 cell apoptosis induced by high temperature and its effect on cell cycle progress[J]. Journal of Jilin University: Med Ed, 2004, 30(1): 103-104 |
| |
| Authors: | FENG Qing-jie DU Bai-shan SHU Chang LI Gang SUN Li-qun |
| |
| Affiliation: | 1. Department of Otorhinolaryngology and Head- Neck Surgery,Second Hospital,Jilin University,Changchun 130041,China;2. Department of Anesthesiology, Second Hospital,Jilin University,Changchun 130041,China |
| |
| Abstract: | Objective To study the relationship between apoptosis and cell cycle with Hep 2 cell apoptosis induced by high temperature.Methods To examine Hep 2 cell proliferation inhibitory rate,apoptosis and different phase of cell cycle with MTT colorimetry and flow cytometry.Results The difference of Hep 2 apoptosis rate between heating group and control group was obviously significant;The different of Hep 2 proliferation inhibitory rate between heating group and control group with MTT colorimetry was obviously significant ( P <0 01).Conclusion High temperature can increase Hep 2 cell apoptosis and inhibit the cell cycle progress of Hep 2 from G 1 stage to S stage. |
| |
| Keywords: | apoptosis/physiology cell cycle/physiology hyperthermia induced |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《吉林大学学报(医学版)》浏览原始摘要信息 |
|
点击此处可从《吉林大学学报(医学版)》下载全文 |
