直肠非霍奇金淋巴瘤并发直肠腺癌一例

目的报道1例直肠非霍奇金淋巴瘤（HNL）并发同一部位直肠腺癌病例。方法中山大学附属第一医院于2010年5月19日收治了1例直肠HNL合并同一部位直肠腺癌的71岁男性患者,对其临床表现、诊治过程及术后病理特征进行总结。结果该病例术前诊断为重度不典型增生伴腺瘤局部癌变,术前分期为T2N0-1M0。行Parks手术（直肠切除结肠肛管吻合术）加肝左外叶次全切除术;术程顺利,术后恢复良好。术后病理结果显示：直肠中分化管状腺癌．侵犯直肠深肌层;直肠NHL,边缘区细胞性;远、近切缘均阴性,无脉管和神经侵犯。免疫组织化学（免疫组化）染色不：L26（＋）,Bcl-2（＋）,Bcl-6（＋）,CD3（-）,CD23（-）,CK上皮细胞（＋）,M-CEA腔缘（＋）。肝脏标本病理及免疫组化检测结果符合肝黏膜相关边缘区淋巴瘤。结论直肠同一部位同时发生腺癌和淋巴瘤极其罕见．其具有独特的病理特征。

Rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma:a case report and literature review

Objective To report a case of rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma. Methods Clinical records of a 71 years old male patient with rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma admitted on May 19, 2010 to the First Affiliated Hospital of Sun Yet-sen University were retrospectively reviewed. Clinical manifestations, diagnosis, and treatment as well as postoperative pathology were summarized. Results The preoperative diagnosis of the patient was severe atypical adenomatous hyperplasia with focal carcinogenesis, and the preoperative staging was T2N0-1M0. The patient underwent a Parks procedure (rectal resection and coloanal anastomosis) and subtotal resection of left lateral liver. The operation was successful, postoperative recovery uneventful. Postoperative pathology showed moderately differentiated tubular adenocarcinoma with deep muscular invasion, and non-Hodgkin lymphoma with marginal zone cell. Both the distal and proximal resection margins were negative and no vascular and neural invasion were seen. Immunohistochemical staining indicated L26 (+), Bcl-2 (+), Bcl-6 (+), CD3 (-), CD23 (-), CK epithelial cells (+), and M-CEA luminal border (+). The pathological and immunohistochemistry results of liver specimens showed hepatic mucosa-associated marginal zone lymphoma. Conclusions Rectal adenocarcinoma and lymphoma occurring at the same site simultaneously is extremely rare with unique pathologic features.