急性脑梗死患者外周血炎性指标测定的临床意义

目的:探讨急性脑梗死患者外周血hs-CRP、CD3+/HLA-DR+和中性粒细胞CD64指数测定的临床意义。方法:采用免疫透射比浊法及流式细胞学检测80例急性脑梗死患者(梗死组)及50例健康体检者(对照组)的外周血hs-CRP、CD3+/HLA-DR+和中性粒细胞CD64指数水平。结果:梗死组hs-CRP水平、CD3+/HLA-DR+水平均明显高于对照组(P<0.01),并与NIHSS评分显著正相关,hs-CRP水平与CD3+/HLA-DR+水平亦呈正相关。梗死组中性粒细胞CD64指数与对照组比较差异无统计学意义。结论:炎性反应参与急性脑梗死的发病过程,外周血hs-CRP和CD3+/HLA-DR+可用于判断急性脑梗死的严重程度,中性粒细胞CD64指数与急性脑梗死的关系尚未明确。

Clinical Significance of Inflammatory Parameters in Peripheral Blood in Patients with Acute Cerebral Infarction

Objective:To explore clinical significance of inflammatory factors in the peripheral blood in patients with infarction.Methods:The levels of highly sensitive C-reactive protein(hs-CRP),CD3+/HLA-DR+ and neutrophil CD64 index in 80 cases with acute cerebral infarction(infarction group) and 50 healthy controls(control group) were detected by immune turbidimetry and flow cytometry respectively.Results:The levels of hs-CRP and CD3+/HLA-DR+ in infarction group significantly higher than control group(P<0.01),showing a positive correlation with their NIHSS score.In the infarction group,the level of hs-CRP also had a positive correlation with CD3+/HLA-DR+.There was no difference between the neutrophil CD64 index of infarction group and that of control group.Conclusion:Inflammatory reaction is involved in the pathogenesis of acute cerebral infarction.The levels of hs-CRP and CD3+/HLA-DR+ are significantly elevated in patients with acute cerebral infarction,except neutrophil CD64.