High-dose chemotherapy with peripheral blood stem cell transplantation for patients with advanced ovarian cancer |
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Authors: | Peter Bojko Max Ernst Scheulen Ralf Hilger Carsten Oberhoff Adolf Eduard Schindler Siegfried Seeber |
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Institution: | (1) University of Essen, Department of Internal Medicine, West German Cancer Center, Hufelandstrasse 55, 45122 Essen, Germany Tel.: +49-201-7232012; Fax: +49-201-7235736, e-mail: peter.bojko@uni-essen.de, DE;(2) University of Essen, Department of Gynaecology and Obstetrics, Essen, Germany, DE |
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Abstract: | Purpose: We report the results of high-dose chemotherapy (HDC) with peripheral blood stem cell transplantation in twenty-one patients
with primarily advanced or relapsed ovarian cancer. Methods: Twenty-five women underwent stem cell collection, and 21 were finally treated with different regimens of HDC containing cyclophosphamide,
etoposide, carboplatin, and treosulfan. The patients received cyclophosphamide ± cisplatin and cisplatin + paclitaxel, respectively,
followed by G-CSF (n=24) or GM-CSF (n=1) for stem cell mobilization. Results: A mean of 7.2 ± 6.1 × 106 CD34+ cells per kg bw were collected. Thirteen patients received double transplants and one patient received a triple transplant.
The median age was 47 years (range 24–61 years) and the mean number of prior regimens was three (range 1–8). Engraftment occurred
on time in all patients and there was one treatment-related death resulting in an overall mortality rate of 4.8% among the
21 patients treated with HDC. The response rate was 72% (48% CR, 24% PR) and the mean time to progression and overall survival
after HDC were 7 and 32 months, respectively. Conclusion: HDC could be performed safely in patients with advanced ovarian cancer. However, even with a high response rate, the duration
of response is short, warranting new treatment approaches to further improve the outcome of this population of patients with
unfavorable prognosis.
Received: 19 July 2000 / Accepted: 25 August 2000 |
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Keywords: | Ovarian cancer High-dose chemotherapy |
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