Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese apricot |
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| Authors: | Miyazawa Mitsuo Utsunomiya Hirotoshi Inada Ken-Ichi Yamada Tomoki Okuno Yoshiharu Tanaka Harunari Tatematsu Masae |
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| Affiliation: | Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University. miyazawa@apch.kindai.ac.jp |
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| Abstract: | A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml. |
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