| 模拟失重对大鼠后肢动脉血管床血管反应性的影响 |
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| 引用本文： | 马进,张乐宁,张立藩,杨天德.模拟失重对大鼠后肢动脉血管床血管反应性的影响[J].航天医学与医学工程,1999,12(4):254-257. |
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| 作者姓名： | 马进 张乐宁 张立藩 杨天德 |
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| 作者单位： | 1. 第四军医大学航空生理学教研室,西安710032
2. 航天医学工程研究所,北京,100094 |
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| 摘 要： | 目的 观察模拟失重对大鼠后肢血管床血管反应性的影响。方法 采用尾部悬吊大鼠模型模拟失重，利用离体后肢恒流灌流技术测定模拟失重２ｗｋ后动及血管床反应性的变化。
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| 关 键 词： | 模拟失重 血管反应性 大鼠 动脉 |
| 文章编号： | 1002-0837(1999)04-0254-04 |
| 修稿时间： | 1998-10-19 |
Effects of Simulated Weightlessness on Vasoreactivity of Hindlimb Arterial Bed in Rats |
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| MA Jin,ZHANG Le-ning,ZHANG Li-fan,YANG Tian-de.Effects of Simulated Weightlessness on Vasoreactivity of Hindlimb Arterial Bed in Rats[J].Space Medicine & Medical Engineering,1999,12(4):254-257. |
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| Authors: | MA Jin ZHANG Le-ning ZHANG Li-fan YANG Tian-de |
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| Affiliation: | Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an, China. |
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| Abstract: | Objective: To investigate the alterations in vasoreactivity of hindlimb arterial bed after simulated weightlessness. Method: The tail-suspended rat model was used to simulate weightlessness, and the alterations in vasoreactivity of arterial bed were examined in vitro using isolated, constant flow perfused hindlimb of 2-wk suspended rats and control rats. Result: Perfusion flow-pressure relationship of hindlimb arterial bed showed no significant differences between suspended rats and control rats; but vascular responses to KCl (20-100 mM) and PE(10(-8)-10(-4) M) were decreased in hindlimb arterial bed of suspended rats as compared with that of control rats. Conclusion: Contractile ability of resistance vessels was diminished in simulated weightlessness rats, and a compromised ability of resistance vessels to increase peripheral resistance may play an important role in occurrence of orthostatic intolerance. |
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| Keywords: | simulated weightlessness vasoreactivity rats arteries |
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