Cytoplasmic immunoglobulins in chronic B-lymphoid leukemia |
| |
| Authors: | J F Filippi C Nicolino-Brunet N Tubiana Y Carcassonne J Sampol |
| |
| Affiliation: | Laboratoire d'Hématologie Biologique, Faculté de Médecine et de Pharmacie, Marseille, France. |
| |
| Abstract: | Chronic lymphocytic leukemia B-cells (B-CLL cells) have surface immunoglobulin (Smlg). In addition, cytoplasmic immunoglobulins (Clg) have been reported in chronic lymphocytic leukemia B-cells and are useful for ascertaining monoclonality of the disease. In a study of 60 cases of chronic lymphocytic leukemia B-cells, surface immunoglobulin determinations alone demonstrated monoclonality in 38% of cases, versus 65% of cases with combined surface immunoglobulin and cytoplasmic immunoglobulins determinations. Membrane markers were studied using a panel of monoclonal antibodies. Thirty-six per cent of patients were positive for CD 10. No correlations were seen between immunologic markers and clinical stage. |
| |
| Keywords: | |
|
|
