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慢性乙型肝炎拉米呋定治疗前后组织学变化的病理研究
引用本文:刘伟,罗婵. 慢性乙型肝炎拉米呋定治疗前后组织学变化的病理研究[J]. 临床消化病杂志, 2001, 13(1): 19-20
作者姓名:刘伟  罗婵
作者单位:南京东南大学医学院附属南京第二医院,
摘    要:目的 :探讨慢性乙型肝炎患者拉米呋定治疗前后肝组织学的变化。方法 :随机选择 2 0例慢性乙型肝炎患者 ,口服拉米呋定 ,10 0mg/d× 1y ,治疗前后作肝组织活检、病理检查。结果 :14例患者肝组织炎症明显减轻 ,治疗前后比较 ,呈现显著差异 (P <0 .0 5 )。 2例患者肝组织纤维化减轻 ,治疗前扣比较 ,差异不显著 (P >0 .0 5 )。结论 :拉米夫定可以有效减轻慢性乙型肝炎患者的肝组织炎症 ,但改善肝组织纤维化效果不明显。

关 键 词:慢性乙型肝炎 拉米夫定 肝组织 炎症 纤维化 治疗
修稿时间:2000-07-10

The Pathological Study on the Changes of the Patients Liver Tissue Before and After Treatment of Lamivudine with Chronic Hepatitis B
Liu Wei,Lo Chan. The Pathological Study on the Changes of the Patients Liver Tissue Before and After Treatment of Lamivudine with Chronic Hepatitis B[J]. Chinese Journal of Clinical Gastroenterology, 2001, 13(1): 19-20
Authors:Liu Wei  Lo Chan
Affiliation:Liu Wei,Lo Chan Department of Pathology,the Affiliated Nanjing Second Hospital of the Medical College of Nanjing Dongnan Universtity
Abstract:Purpose: To study the changes of the patients liver tissue before and after treatment of lamivudine with chronic hepatitis B. Methods: 20 patients with chronic hepatitis B was treated with lamivudine (100 mg/d × 1y) and examined the changes of the liver tissue with pathological methods. Results: After treatment of lamivudine, for the patients with chronic hepatitis B, 17/20 (85%) cases were remarkably reduced in the inflammatory activity of the liver tissues, the results was significant difference ( P <0.05); 2/20 ( 10 % ) cases werent remarkably reduced in the liver tissues fibrosis activity, the results wasnt significant difference (P> 0.05). Conclusion: Lamivudine maybe reduce the inflammatory activity and maybe not reduce the liver tissues fibrosis activity of liver tissues for patients with chronic hepatits B.
Keywords:Chronic hepatitis B Lamivudine Liver tissue Inflammatory activity Fibrosis activity
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