Dog-1、CD117、CD34在胃肠道间质瘤中的表达及意义

目的探讨胃肠道间质瘤（GIST）的临床病理和免疫组织化学特征。方法观察40例GIST的临床表现及病理形态特征，并用免疫组织化学方法检测Dog-1、CD117、CD34、SMA和S-100的表达情况。结果40例GIST的主要临床症状表现为胃部不适，其中以腹胀或腹痛最为常见。病理形态学特征表现为三种类型：梭形细胞型28例、上皮样细胞型8例和混合细胞型4例。免疫组化显示Dog-1、CD117、CD34在GIST中的阳性表达率分别为90％、90％、70％，SMA、S-100大部分病例为阴性表达，仅少数病例呈局灶阳性表达。结论GIST无特征性的临床表现，病理组织形态多变、结构多样，联合检测Dog-1、CD117、CD34的表达对其诊断及鉴别诊断有重要意义。

Expression and Significance of Dog-1,CD117 and CD34 in Gastrointestinal Stromal Tumors

Objective To investigate the clinicopathologic and immunohistochemical features of gastrointestinal stromal tumors （GISTs）. Methods A total of 40 cases of GISTs were studied by histological evaluation along with immunohistochemistry analysis, ineluding Dog-l.CDI17.CD34.SMA and S-100. Results Patients of GISTs presented with stomach discomfort, and the most common symptoms were abdominal pain and abdominal distention. There were three major morphologic types： spindle cell type （28 cases）,epithelioid cell type （8 cases） and mixed cell type （4 cases）. Dog-I.CDll7 were both positive in 90% of GISTs,and CD34 was positive in 70% of GISTs. SMA and S-100 were partly expressed or usually absent. Conclusion GISTs have varied cell types and different arrangements, and lack of distinctive clinical manifestation; Dog-1 、CD117 and CD34 staining can be used in diagnosis and differential diagnosis of GISTs.