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Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain Acta 1383 |
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| Authors: | Baur Stefanie Niehaus Jörg Karagouni Amalia D Katsifas Efstathios A Chalkou Kalliopi Meintanis Christos Jones Amanda L Goodfellow Michael Ward Alan C Beil Winfried Schneider Kathrin Süssmuth Roderich D Fiedler Hans-Peter |
| Affiliation: | Mikrobiologisches Institut, Universit?t Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany. |
| Abstract: | Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines. |
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