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Acquired intestinal aganglionosis after a lytic infection with varicella-zoster virus |
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| Authors: | Holland-Cunz Stefan Göppl Max Rauch Ulrich Bär Claudia Klotz Markus Schäfer Karl-Herbert |
| Institution: | a Department of Pediatric Surgery, University of Heidelberg, 69120 Heidelberg, Germany b Department of Biotechnology, University of Applied Sciences Kaiserslautern, 66482 Zweibrücken, Germany c Department of Pediatric Oncology, University of Heidelberg, 69120 Heidelberg, Germany d Department of Pediatric Surgery, University Hospital Mannheim, Clinical Faculty Univ. Heidelberg, 68123 Mannheim, Germany |
| Abstract: | Background and PurposeIn this report, we present the first case of an immunologically impaired child surviving a lytic varicella-zoster virus infection affecting the enteric nervous system. In histological findings, myenteric and submucous enteric ganglia were nearly completely absent owing to virus infection.MethodsA 3-year-old girl with acute lymphoblastic leukemia and generalized varicella-zoster infection developed an ileus. She underwent multiple laparotomies in which histological sections of the entire small intestine could be obtained.ResultsThe histological evaluation of these samples showed a generalized aganglionosis with inflammatory residuals. A more detailed immunohistochemical analysis using neuronal (PGP, enolase), glial (S100), and lymphocytic (LCA) antibodies demonstrated a nearly complete neuronal loss.ConclusionTo our knowledge, this is the first case of a secondary intestinal aganglionosis after varicella-zoster virus infection. |
| Keywords: | Intestinal aganglionosis Varicella-zoster infection Acute lymphoblastic leukemia |
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