高同型半胱氨酸血症与脑卒中关系的临床分析

目的探讨高同型半胱氨酸(Hcy)血症与脑卒中的关系。方法选取2010年10月至2011年10月西安市第一医院收治的96例脑卒中患者为病例组,选取同期96例健康体检者为对照组,采用液相色谱法测定两组患者血清中总Hcy水平,同时检测叶酸、维生素B12的浓度。结果病例组患者血清Hcy浓度高于对照组(P<0.05);复发性脑梗死组的血清Hcy浓度高于首次发作脑梗死组的Hcy浓度(P<0.05)。结论高Hcy血症是脑卒中的独立危险因素,叶酸和维生素B12的缺乏可能是导致高Hcy血症的原因之一。

Clinical Analysis of Hyperhomocysteinemia and Stroke

Objective To explore the relationship between hyperhomocysteinemia and stroke.Methods 96 patients with stroke admitted to Xi′an First Hospital during Oct.2010 to Oct.2011 were selected as the case group,another 96 cases of healthy persons were selected as control group,serum total Hcy levels of the two groups were determined using liquid chromatography,and the folic acid,vitamin B12 concentration were tested.Results Serum Hcy concentration of the stroke group was higher than that of the control group(P<0.05);sserum Hcy of recurrent cerebral infarction cases was higher than the first attack cases(P<0.05).Conclusion Hyperhomocysteinemia is an independent risk factor for stroke,folic acid and vitamin B12 deficiency may be one of the reasons leading to hyperhomocysteinemia.