阿魏酸钠对糖尿病早期肾损害患者血浆内皮素-1、肾功能的影响

目的探讨阿魏酸钠对糖尿病患者早期肾损害的治疗价值。方法将80例伴有微量白蛋白尿的2型糖尿病患者随机分为常规治疗组（RTG组）和阿魏酸钠治疗组（SFG组）。比较治疗前后血脂、内皮素-1（ET-1）、血尿β2-微球蛋白（β2-MG）及尿微量白蛋白（Alb）的变化。结果与治疗前比较,SFG组血尿β2-MG、尿Alb及血ET-1均显著降低（P〈0.01）,并且脂质代谢紊乱亦有改善;而RTG组血尿β2-MG、尿Alb及血ET-1治疗前后比较,差异无统计学意义（P〉0.05）。结论阿魏酸钠治疗能改善血管内皮功能,逆转糖尿病患者的早期肾损害。

Effect of sodium ferulate on vascular endothelial-1 kidney function of patients with early stage diabetic nephropathy

Objective To observe the effect of sodium ferulate on early renal damage in patient with diabetic nephropathy.Methods 80 cases with microalbuminuria in patients with type 2 diabetes were randomly divided into routine treatment group(RTG) and sodium ferulate treatment group(SFG),The changes of the lipids,endothelin-1,serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin before and after treatment were compared between the two groups.Results After the treatment,the levels of serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin and endothelin-1 in the SFG significantly decreased(P<0.01),and the disorder of lipid metabolism improved;the levels of serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin and endothelin-1 in RTG had no statistical difference before and after treatment(P<0.01).Conclusion Treatment of sodium ferulate can improve vascular endothelial function,reverse the early renal damage in patients with diabetic.