白细胞介素-4基因-590C/T多态性与慢性牙周炎易感性的Meta分析

目的:通过文献评价探讨白细胞介素-4(interleukin-4,IL-4)-590C/T基因多态性与慢性牙周炎(chronic periodontitis,CP)易感性之间的关系.方法:检索8个数据库,搜集国内外有关病例对照研究文献.根据种族进行亚组分析,采用Meta分析评估IL-4基因多态性与CP的关联性,同时进行发表偏倚的检验和异质性分析,并对结果进行敏感性分析 . 结果:最终有8个研究纳入系统评价,病例组628例,健康对照组717例 . Meta分析结果显示,IL-4基因-590C/T位点等位基因频率及基因多态性与研究人群CP易感性间均无显著相关性.进一步亚组分析显示,对于C等位基因而言,携带T等位基因增加了高加索人患CP的风险(C vs.T:OR=0.71,95％CI=0.56～0.89);高加索人种CP的易感性与-590C/T位点多态性显著相关(C vs.T:OR=0.71,95％CI=0.56～0.89;CC vs.CT:OR =0.60,95％CI=0.38～0.94;隐性模型CC vs.CT+TT:OR =0.61,95％CI=0.42～0.88),即高加索人中携带CC基因型者较携带CT与TT基因型者患CP风险减少39％,而亚洲人CP的易感性与该基因无显著相关性.结论:IL-4基因-590C/T位点多态性与高加索人CP易感性有一定相关性.这一结论尚需要大规模、多种族的流行病学研究加以验证.

Association between-590C/T polymorphisms of interleukin-4 gene and chronic periodontitis: A meta-analysis

PURPOSE: To evaluate the relationship between-590C/T polymorphisms of interleukin-4 gene and chronic periodontitis using meta-analysis.METHODS: The selected studies were pooled from eight major electronic databases for case-control study.To gain a more precise estimation of the relationship,a stratified meta-analysis with two subgroups was performed according to the races.Heterogeneity,publication bias and sensitivity analysis were also explored.RESULTS: Totally 8 studies were recruited.Total sample sizes for chronic periodontitis and control groups were 628 and 717, respectively.Meta-analysis showed that both-590C/T polymorphisms and allele frequency were not significantly associated with chronic periodontitis.In subgroup analysis,a significant association of increased chronic periodontitis risk and T allele was found.The results also indicated a significant correlation between-590C/T polymorphisms of IL-4 and Caucasian who suffered from chronic periodontitis(C vs.T: OR=0.71,95%CI=0.56-0.89;CC vs.CT:OR=0.60,95%CI=0.380.94;recessive genetic model CC vs.CT +TT:OR =0.61,95% CI =0.42-0.88),further analysis of the results showed the CC genotype was about 39% less likely to have chronic periodontitis than the CT and TT genotype in Caucasian individuals. However,these significant associations was not found in Asian group.CONCLUSIONS: The meta-analysis suggests there may be an important effect of single nucleotide polymorphisms(SNPs) in the promoter region of IL-4 gene on the pathogenesis of chronic periodontitis in Caucasian.This warrants further investigation in larger studies and multi-race epidemiological to evaluate the results.