| 胆甾醇琥珀酰基白芨多糖的制备及其理化性质研究 |
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| 引用本文： | 毕亚静,王艳萍,刘福强,赵楠,刘丹,韩丹,刘天娇. 胆甾醇琥珀酰基白芨多糖的制备及其理化性质研究[J]. 药学实践杂志, 2013, 31(3): 220-223 |
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| 作者姓名： | 毕亚静 王艳萍 刘福强 赵楠 刘丹 韩丹 刘天娇 |
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| 作者单位： | 毕亚静 (延边大学药学院,吉林延吉133000;解放军208医院,吉林长春130062)； 王艳萍 (解放军208医院,吉林长春,130062)； 刘福强 (解放军208医院,吉林长春,130062)； 赵楠 (解放军208医院,吉林长春,130062)； 刘丹 (解放军208医院,吉林长春,130062)； 韩丹 (延边大学药学院,吉林延吉,133000)； 刘天娇(延边大学药学院,吉林延吉,133000)； |
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| 基金项目： | 国家自然科学基金项目(项目编号：81173559) |
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| 摘 要： | 目的 对白芨多糖疏水改性,并测其分子量和研究其理化性质。方法 以白芨多糖为原料,合成胆甾醇琥珀酰基-白芨多糖;用红外光谱对结构进行表征;用高效凝胶渗透色谱法测分子量。结果 合成了胆甾醇琥珀酰基白芨多糖;分子量为650 kDa;其理化性质:pH 6.89;黏度130 mPa·s;等电点 5.07;溶解度 0.9 g。结论 合成方法可行,得率稳定,为进一步扩大试验提供了研究基础。
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| 关 键 词： | 白芨多糖 胆甾醇琥珀酰基 合成 理化性质 |
| 收稿时间： | 2012-12-26 |
| 修稿时间： | 2013-05-01 |
Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide |
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| BI Ya-jing,WANG Yang-ping,LIU Fu-qiang,ZHAO Nan,LIU Dan,HAN Dan and LIU Tian-jiao. Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide[J]. The Journal of Pharmaceutical Practice, 2013, 31(3): 220-223 |
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| Authors: | BI Ya-jing WANG Yang-ping LIU Fu-qiang ZHAO Nan LIU Dan HAN Dan LIU Tian-jiao |
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| Affiliation: | School of Pharmacy, Yan Bian University, Yanji 133000, China;The 208th Hospital of PLA, Changchun 130062, China,The 208th Hospital of PLA, Changchun 130062, China,The 208th Hospital of PLA, Changchun 130062, China,The 208th Hospital of PLA, Changchun 130062, China,The 208th Hospital of PLA, Changchun 130062, China,School of Pharmacy, Yan Bian University, Yanji 133000, China and School of Pharmacy, Yan Bian University, Yanji 133000, China |
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| Abstract: | Objective To determination the molecular weight and studies on its properties after hydrophobic modification of Bletilla striata polysaccharide. Methods Bletilla striata polysaccharide were used as the starting materials, which reacted with cholesterol succinate to afford a derivate of cholesterol succinate polysaccharide, characterizate its structure by infrared spectroscopy, determinate its molecular weight by Sephadex chromatography(HPGPC). Results Acholesterol succinate polysaccharide was synthesized:molecular weight 650 kDa, pH 6.89, viscosity 130 mpa, isoelectric point 5.07, solubilit 0.9 g. Conclusion The method of synthesis was feasible and stable, which provided valuable research base for expand test. |
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| Keywords: | Bletilla striata polysaccharide cholesterol succinatel synthesis physical and chemical properties |
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