| 瓜蒌的化学成分研究 |
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| 引用本文： | 孙晓业,吴红华,付爱珍,张鹏.瓜蒌的化学成分研究[J].药学学报,2012(7):922-925. |
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| 作者姓名： | 孙晓业 吴红华 付爱珍 张鹏 |
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| 作者单位： | 天津中医药大学,天津市现代中药重点实验室,天津市中药化学与分析重点实验室;天津国际生物医药联合研究院 |
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| 基金项目： | 国家重点基础发展计划(重大疾病治疗药物药理学研究、活血化瘀类中药调节血管收缩舒张功能的物质基础和作用机理)资助项目(2011CB512008);现代中药新药发现和评价技术平台建设资助项目(2012ZX09103201-031) |
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| 摘 要： | 为了研究瓜蒌(Trichosanthes kirilowii Maxim.)的化学成分,利用D101大孔树脂、硅胶、SephadexLH-20、ODS等柱色谱和制备液相等各种色谱手段对其95%乙醇提取物进行系统的分离和纯化,共得到9个化合物。其结构经1H NMR、13C NMR、1H-1H COSY、HSQC、HMBC、ESI-MS技术分别鉴定为1-羧丙基-5-乙氧甲基-1H-吡咯-2-醛-吡咯(5-ethoxymethyl-1-carboxyl propyl-1H-pyrrole-2-carbaldehyde,1)、5-羟甲基糠醛(5-hydroxymethyl-2-furfural,2)、金圣草黄素(chrysoeriol,3)、4’-羟基黄芩素(4’-hydroxyscutellarin,4)、香草酸(vanillic acid,5)、α-菠甾醇(α-spinasterol,6)、α-菠甾醇-β-D-葡萄糖苷(β-D-glucopyranosyl-α-spinasterol,7)、豆甾-7-烯-3β-醇(stigmast-7-en-3β-ol,8)和腺苷(adenosine,9)。其中化合物1为新化合物,化合物3、4、5为首次从该属植物中分离得到。
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| 关 键 词： | 瓜蒌 化学成分 植物甾醇 黄酮 |
Chemical constituents of Trichosanthes kirilowii Maxim. |
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| SUN Xiao-ye,WU Hong-hua,FU Ai-zhen,ZHANG Peng.Chemical constituents of Trichosanthes kirilowii Maxim.[J].Acta Pharmaceutica Sinica,2012(7):922-925. |
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| Authors: | SUN Xiao-ye WU Hong-hua FU Ai-zhen ZHANG Peng |
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| Institution: | 1(1.Tianjin University of Traditional Chinese Medicine,Tianjin Key Laboratory of Modern Chinese Medicine,Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis,Tianjin 300193,China;2.Tianjin International Joint Academy of Biotechnology & Medicine,Tianjin 300457,China) |
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| Abstract: | To study the chemical constituents of Trichosanthes kirilowii Maxim.,chromatographic methods such as D101 macroporous resin,silica gel column chromatographic technology,Sephadex LH-20,octadecylsilyl(ODS) column chromatographic technique and preparative HPLC were used and nine compounds were isolated from a 95%(v/v) ethanol extract of the plant.By using spectroscopic techniques including 1H NMR,13C NMR,1H-1H COSY,HSQC and HMBC,these compounds were identified as 5-ethoxymethyl-1-carboxyl propyl-1Hpyrrole-2-carbaldehyde(1),5-hydroxymethyl-2-furfural(2),chrysoeriol(3),4’-hydroxyscutellarin(4),vanillic acid(5),α-spinasterol(6),β-D-glucopyranosyl-α-spinasterol(7),stigmast-7-en-3β-ol(8),and adenosine(9),separately.Among them,compound 1 is a new compound,and compounds 3,4 and 5 are isolated from the genus Trichosanthes kirilowii Maxim.for the first time. |
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| Keywords: | Trichosanthes kirilowii chemical constituent phytosterol flavone |
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