| 脂质体包裹的氮芥对家兔急性实验性血清病的影响 |
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| 引用本文： | 周凡,朱锡华. 脂质体包裹的氮芥对家兔急性实验性血清病的影响[J]. 第三军医大学学报, 1988, 0(5) |
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| 作者姓名： | 周凡 朱锡华 |
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| 作者单位： | 第三军医大学免疫学教研室(周凡)，第三军医大学免疫学教研室(朱锡华) |
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| 摘 要： | 本实验用脂质体包裹氮芥处理急性实验性血清病家兔,检测了血清抗BSA抗体,循环免疫复合物以及血清补体总活性的动态变化。观察了脾脏巨噬细胞酸性磷酸酶的活性、肾小球内免疫复合物的沉积及肾组织的病理改变。结果表明,氮芥-脂质体能增强急性血清病家兔巨噬细胞的活性,加重肾组织的病理损伤程度,提示家兔急性实验性血清病的发病可能是依赖于单核巨噬细胞的免疫病理机制。
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| 关 键 词： | 氮芥 脂质体 巨噬细胞 免疫复合物病 血清病 |
Effects of Liposome-encapsulated Nitrogen Mustard on Acute Experimental Serum Sickness in Rabbits |
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| Zhou Fan and Zhu Xihua. Effects of Liposome-encapsulated Nitrogen Mustard on Acute Experimental Serum Sickness in Rabbits[J]. Acta Academiae Medicinae Militaris Tertiae, 1988, 0(5) |
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| Authors: | Zhou Fan and Zhu Xihua |
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| Abstract: | Nitrogen mustard encapsulated with liposomes was administered to the rabbits with acute experimental serum sickness(AESS). Then the serum levels of anti-BSA antibodies and circulating; immune complex(CIC), CH50, and WBC count were determined. The ACPase activity of spleen macrophages was measured. And the sections of renal tissues, after HE-stained, were studied for the accumulation of CIC and the pathological changes. It was found that liposome-encapsulated nitrogen mustard can increase the macrophage activity and in turn aggravate the renal damages of AESS rabbits.The results suggest that the renal damages of AESS rabbits can immunopatholo-gically be attributed to the increased activity of macrophages. |
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| Keywords: | Nitrogen mustard Liposomes Macrophages Immune complex disease Serum sickness |
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