| UGTIA1 G71R基因突变对母乳性黄疸发病的影响 |
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| 引用本文： | 傅雯萍,王维亚,张凤梅.UGTIA1 G71R基因突变对母乳性黄疸发病的影响[J].武警医学,2011,22(4):323-325. |
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| 作者姓名： | 傅雯萍 王维亚 张凤梅 |
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| 作者单位： | 武警医学院附属医院儿科,天津,300162 |
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| 摘 要： | 目的 探讨葡萄糖醛酸转移酶UGT1A1 G71R基因突变对母乳性黄疸发病的影响.方法 采用病例对照研究方法,收集母乳性黄疸56例（黄疸组）和对照40例（对照组）.用套式PCR后限制性片段长度多态性分析（RFLP）确定UGT1A1 G71R基因型.通过全自动生化分析仪测定胆红素水平.分析 UGT1A1 G71R突变与母乳性黄疸发病的关系.结果 黄疽组中,UGT1 A1 GT1R突变纯合子5例、杂合子24例、野生型27例,UGT1A1 G71R等位基因频率为30.36%.对照组中,UGT1A1 G71R突变纯合子1例、杂合子9例、野生型30例,UGT1A1 G71R等位基因频率为13.75%.等位基因频率前者明显高于后者,且有统计学意义（X2=7.17,P=0.01）.UGT1A1 G71R突变纯合子或杂合子组婴儿发生母乳性黄疸的OR（95%CI）为3.2（1.32,7.77）.结论 UGT1A1 G71R基因突变可能是晚发性母乳性黄疸发病的促发因素之一.
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| 关 键 词： | 母乳性黄疸 UGT1A1基因 婴儿 |
The effect of the UDP-glucoronosyl transferase transferase l A1 G71 R gene mutation on the development of breast-milk jaundice |
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| FU Wenping,WANG Weiya,ZHANG Fengmei.The effect of the UDP-glucoronosyl transferase transferase l A1 G71 R gene mutation on the development of breast-milk jaundice[J].Medical Journal of the Chinese People's Armed Police Forces,2011,22(4):323-325. |
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| Authors: | FU Wenping WANG Weiya ZHANG Fengmei |
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| Institution: | FU Wenping,WANG Weiya,and ZHANG Fengmei.The Affiliated Hospital of Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China |
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| Abstract: | Objective This study was to investigate the effect of G71R mutation in the first exon of the uridine 5'-diposphate -glucuronosyl transferase 1A1(UGT1A1) gene to the development of late - onset breast - milk jaundice.Methods 96 blood samples had been collected for the identification of UGT1A1 G71R mutation by restriction fragment length polymorphism(RFLP) after nest - polymerase chain reaction.The levels of blood bilirubin were determined by automatic biochemistry analyzer.The infants were allocated into lat... |
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| Keywords: | breast - milk jaundice UGT1A1 gene infant |
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