Calcium blockers enhance cisplatin-induced nephrotoxicity in rats |
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Authors: | J Uozumi T Ueda T Yasumasu Y Koikawa J Kumazawa |
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Institution: | (1) Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
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Abstract: | To examine the effects of calcium blockers on nephrotoxicity caused by cisplatin, the renal function and renal accumulation
of Pt in Sprague-Dawley rats given 6.5 mg/kg i.v. cisplatin simultaneously with several doses of verapamil or nicardipine
were evaluated. BUN, serum creatinine and kidney Pt concentrations in rats given more than 5.0 mg/kg of verapamil were significantly
higher than those of the control animals injected with 6.5 mg/kg i.v. cisplatin alone, and the increase of each value was
dependent upon the dose of verapamil. BUN, creatinine and kidney Pt in rats injected with more than 0.5 mg/kg i. p. nicardipine
were also significantly higher than those of the controls. Calcium blockers enhanced the renal accumulation of Pt and the
nephrotoxicity of cisplatin. |
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Keywords: | |
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