Cefotaxime-induced immune hemolytic anemia due to antibodies reacting in vitro by more than one mechanism |
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| Authors: | IA Shulman, PA Arndt, W McGehee, G Garratty |
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| Affiliation: | Blood Bank and Transfusion Medicine Unit, Los Angeles County-University of Southern California Medical Center. |
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| Abstract: | Until recently, all cephalosporin-induced immune hemolytic anemias appeared to react by a "penicillin-type" drug adsorption mechanism, and hemolysis was extravascular. In 1987 and 1988, the first two cases of cephalosporin-induced immune hemolytic anemia with intravascular hemolysis associated with a so-called immune complex mechanism were reported. This report describes a case of extravascular hemolysis due to a third-generation cephalosporin, cefotaxime, which, to the authors' knowledge, is the first to show in vitro characteristics of both the drug adsorption and the so-called immune complex mechanisms. |
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