血小板活力与胞外钙离子浓度的关系

作者对血小板活力与胞外Ca~(2+)浓度间的关系作了观察。证明在家兔和大鼠的柠檬酸盐抗凝的富含血小板血浆中,以不同的激活剂激活血小板时,其变形速率不因外加不同剂量的Ca~(2+)有所改变;而释放和聚集活力则随外加Ca~(2+)的剂量增加而增加。因此在动物试验中,在其富含血小板血浆中,外加一定量的Ca~(2+)以使血小板活力充分发挥很有必要,以满足当时血小板赖钙反应的进行。

THE CORRELATION BETWEEN PLATELET ACTIVITY AND EXTRACELLULAR CALCIUM CONCENTRATION

An investigation of the correlation between platelet activity and extracellular Ca2+concentration is described.It was demonstrated that in the citrate-platelet-rich-plasma of rabbits and rats,the rate of shape change of the platelets induced by different activators did not alter when different doses of calcium ions were added to the experimental system, while the platelet activity of both secretion and aggregation was increased along with increased doses of calcium ions. Therefore, in the animal experiment addition of an appropriate dose of calcium ions to the citrate-platelet-rich-plasma is necessary to allow full play to the functional activity of platelets, and to maintain calcium-dependent reaction.