| IL-6，Fas与慢性阻塞性肺疾病急性加重期的相关性研究 |
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| 引用本文： | 刘艳红,夏熙郑.IL-6，Fas与慢性阻塞性肺疾病急性加重期的相关性研究[J].中国实用医药,2009,4(2):19-20. |
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| 作者姓名： | 刘艳红 夏熙郑 |
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| 作者单位： | 郑州大学第二附属医院呼吸内科,450000 |
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| 摘 要： | 目的探讨白介素-6（IL-6）与凋亡因子（Fas）在慢性阻塞性肺疾病急性加重期中的作用与意义及二者的相关性。方法用ELISA方法检测35例慢性阻塞性肺疾病急性加重期患者和32例健康对照组血清中IL-6和Fas的水平。结果慢性阻塞性肺疾病急性加重期中IL-6与Fas的水平均显著高于对照组，差异具有显著性意义（P〈0．05）。结论Fas介导COPD患者的免疫细胞凋亡，IL-6与Fas共同参与了COPD的气道炎性反应，对判断COPD的急性加重及呼吸功能具有重要的临床意义。
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| 关 键 词： | 慢性阻塞性肺疾病 Fas／FasL IL-6 |
IL-6,Fas and chronic obstructive pulmonary disease with acute exacerbation of the relevance |
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| LIU Yan-hong,XIA Xi-zheng.IL-6,Fas and chronic obstructive pulmonary disease with acute exacerbation of the relevance[J].China Practical Medical,2009,4(2):19-20. |
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| Authors: | LIU Yan-hong XIA Xi-zheng |
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| Institution: | (Department of Respiratory Medicine, Secomd affiliated Hospital of Zhengzhou University, Henan 450000, China) |
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| Abstract: | Objective To investigate the implication and correlation of serum IL-6 and Fas/Fasl ligand in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods The levels of serum IL-6 and Fas/FasL in 35 patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and 32 healthy control subjects were detected by ELISA. Results The levels of serum Fas and IL- 6 in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） were significantly higher than those in healthy control subjects, there was significant diference between the two groups （P 〈 O. 05 ）. Conclusion The Fas/FasL pathway can mediate apoptosis of immune cells in COPD, serum IL-6 and Fas may participate in the airway inflammatory process of COPD and may have important clinic significance in assessing acute exacerbation and pulmonary function of COPD. |
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| Keywords: | Chronic obstructive pulmonary disease（COPD） IL-6 Fas FasL |
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