| 马钱子超微粉体和常规粉体中马钱子碱的溶出比较 |
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| 引用本文： | 邹龙,桂卉,黄世超,蔡光先,唐正平. 马钱子超微粉体和常规粉体中马钱子碱的溶出比较[J]. 中华中医药杂志, 2009, 0(2) |
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| 作者姓名： | 邹龙 桂卉 黄世超 蔡光先 唐正平 |
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| 作者单位： | 湖南中医药大学;湖南省中医药研究院; |
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| 基金项目： | 国家科技攻关课题(No.2001BA701A43); 湖南省科技厅科研科技计划重点项目(No.06Sk2005) |
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| 摘 要： | 目的:对马钱子超微粉体和常规粉体溶出度进行试验,考察超微粉碎对马钱子碱溶出量和溶出速率的影响。方法采用HPLC法测定马钱子常规粉体,超微粉体中马钱子碱体外溶出量和溶出速度。结果:马钱子超微粉体中马钱子碱溶出速度高于其常规粉体,但溶出4h后溶出量无显著性差异。结论:马钱子超微粉碎并不会造成马钱子碱的损失,且可明显提高其溶出速度。
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| 关 键 词： | 马钱子 超微粉体 常规粉体 马钱子碱 体外溶出 |
Comparative study on dissolution of strychnine in normal and ultra-micro powder of semen strychi |
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| ZOU Long,GUI Hui,HUANG Shi-chao,CAI Guang-xian,TANG Zheng-ping. Comparative study on dissolution of strychnine in normal and ultra-micro powder of semen strychi[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2009, 0(2) |
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| Authors: | ZOU Long GUI Hui HUANG Shi-chao CAI Guang-xian TANG Zheng-ping |
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| Affiliation: | ZOU Long1,GUI Hui1,HUANG Shi-chao1,CAI Guang-xian1,TANG Zheng-ping2(1Hunan University of Chinese Medicine,Changsha 410007,China,2Hunan Academy of Chinese Medicine,Changsha 410006,China) |
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| Abstract: | Objective:Dissolution test was applied to study the dissolution rates of strychnine from the normal and ultramicro powder of semen strychi. Methods:HPLC techniques was used to detect the dissolution amount and the dissolution velocity of strychnine from the normal and ultra-micro powder of semen strychi. Results:The dissolution velocity of strychnine from the ultra-micro powder was higher than that from the normal powder,but there was no difference in the dissolution amount 4 hours later. Conclusion:The dis... |
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| Keywords: | Semen strychi Ultra-micro powder Normal powder Strychnine Vitro dissolution |
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